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Posluma

flotufolastat F 18
Used for Diagnosis
Used for Diagnosis

Posluma (flotufolastat F 18) is an radiopharmaceutical imaging agent that helps providers see areas of prostate cancer on a specific test known as a prostate-specific membrane antigen – positron emission tomography (PSMA-PET) scan. It’s for people with prostate cancer that might have come back after initial treatment (recurrent) or spread (metastasized) to other parts of the body. It’s given as an infusion through the vein before the PET scan. Side effects include diarrhea, injection site pain, and a rise in blood pressure.

Last reviewed on December 17, 2023
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What is Posluma (flotufolastat F 18)?

What is Posluma (flotufolastat F 18) used for?

How Posluma (flotufolastat F 18) works

Posluma (flotufolastat F 18) is a radiopharmaceutical. It attaches to a particular protein found on the surface of certain cancer cells called prostate-specific membrane antigen (PSMA). Once attached, the radioactive portion of Posluma (flotufolastat F 18) lights up the areas with prostate cancer on a certain type of scan called a PSMA PET scan.

Drug Facts

Common BrandsPosluma
Drug ClassRadiopharmaceutical
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
faqs

Frequently asked questions about Posluma (flotufolastat F 18)

Is Posluma (flotufolastat F 18) FDA approved?
Yes. The FDA approved Posluma (flotufolastat F 18) in May 2023.
Is Posluma (flotufolastat F 18) chemotherapy?
No, Posluma (flotufolastat F 18) isn’t chemotherapy. Chemotherapy works by killing all fast-growing cells, including tumor cells. Posluma (flotufolastat F 18) doesn’t directly damage cancer cells. Instead, it lights up areas with prostate cancer so that your provider can see where the cancer is located. With that information, your provider can come up with a better treatment plan for you.
What side effects can I expect with Posluma (flotufolastat F 18)?
In studies, Posluma (flotufolastat F 18) didn’t have many side effects. In rare situations, some people reported diarrhea, a rise in blood pressure, and pain at the injection site. Talk with your provider if you’re concerned about side effects with this medication.
Does Posluma (flotufolastat F 18) detect all prostate cancer?
Not necessarily. With any test, there’s always a risk of detecting cancer when there isn’t any, or not detecting any cancer when there actually is cancer present. It’s likely that your treatment team will use the information from your scan together with blood tests and tissue samples to confirm your diagnosis and determine your treatment plan. If you are worried about a scan using the medication, discuss your concerns with your provider.
How should I prepare for a PET scan with Posluma (flotufolastat F 18)?
It’s a good idea to stay well-hydrated and urinate right before your PET scan with Posluma (flotufolastat F 18). After your scan, continue to stay hydrated and urinate frequently to reduce radiation exposure.
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alternatives

What are alternatives to Posluma (flotufolastat F 18)?

There are a number of medications that your doctor can prescribe in place of Posluma (flotufolastat F 18). Compare a few possible alternatives below.
Posluma (flotufolastat F 18)
Used for:
Used for:
  • Men with treatable prostate cancer that might have spread to other organs

  • Men with a history of prostate cancer that has come back based on high levels of prostate-specific antigen (PSA)

Used for:

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References

Best studies we found

Blue Earth Diagnostics. (2023). Posluma- flotufolastat f-18 injection [package insert]. DailyMed.

Chang, S. S. (2004). Overview of prostate-specific membrane antigen. Reviews in Urology.

Munjal, A., et al. (2023). Radiopharmaceuticals. StatPearls.

View All References (1)

U.S. Food and Drug Administration. (2023). Novel drug approvals for 2023.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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