Key takeaways:
Cefpodoxime (Simplicef, Vantin, Cefpoderm) is an FDA-approved antibiotic for treating skin infections in dogs.
Most dogs tolerate cefpodoxime with few side effects. But some dogs may get sick to their stomachs, which is common with antibiotics.
Cefpodoxime is available only as a prescription from a veterinarian and comes in tablet form.
Cefpodoxime (Simplicef, Vantin, Cefpoderm) for dogs is an antibiotic that is widely used to treat bacterial infections in various parts of the body. It’s typically prescribed as a once-daily oral antibiotic for skin infections.
Below, we’ll cover how cefpodoxime works, what it’s used for in dogs, side effects, and medication interactions.
Cefpodoxime for dogs at a glance
Common names | Cefpodoxime proxetil (Simplicef, Vantin, Cefpoderm) |
What it treats | Bacterial infections |
How it comes (forms) | Tablets, oral suspension |
Common side effects | Vomiting and diarrhea |
Average cost | $12-$21 for 7 tablets (100 mg) |
What is cefpodoxime for dogs, and how does it work?
Cefpodoxime for dogs is an antibiotic from the cephalosporin medication class. Cefpodoxime is called a broad-spectrum antibiotic because it can treat a wide range of bacterial infections. It becomes active in the gastrointestinal tract and kills bacteria by damaging the bacterial cell wall.
What is cefpodoxime used for in dogs?
Cefpodoxime for dogs is FDA approved to treat certain skin infections in dogs. It’s effective against wounds and abscesses caused by strains of Staphylococcus, E. coli, and other harmful bacteria.
All other uses of cefpodoxime in dogs are considered off-label. These include treating respiratory, ear, and urinary tract infections.
Cefpodoxime doesn’t treat all bacterial infections, and it’s not effective against parasitic, viral, or fungal infections.
What is the cefpodoxime dosage for dogs?
Cefpodoxime is a prescription antibiotic that is most commonly given to dogs as a tablet. It typically comes in a 100 mg or 200 mg tablet that can be broken in half if necessary. Cefpodoxime is also available as a liquid oral suspension.
The dosage of cefpodoxime for dogs is usually 5 mg to 10 mg per kilogram of body weight once daily, with or without food. Your veterinarian will determine the appropriate dosage for your dog.
What are the common side effects of cefpodoxime in dogs?
In general, cefpodoxime is well tolerated by most dogs. The most common side effects of cefpodoxime in dogs are related to the gastrointestinal tract, including:
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These are common with all antibiotics. If you notice these side effects in your dog, consult your veterinarian.
What are the most serious risks of cefpodoxime for dogs?
The most serious side effects of cefpodoxime occur in dogs who have an allergy to cephalosporin antibiotics. Signs of an antibiotic allergy include:
Rash
Pale gums
Hives or facial swelling
Contact your veterinarian immediately if you suspect your dog is having an allergic reaction to cefpodoxime.
In addition, cefpodoxime should not be used — or should be used with caution — in dogs with allergies to:
Penicillin antibiotics
Rapamycin
Carbapenem antibiotics
All cephalosporin medications, including cefpodoxime, should be used with caution in dogs who have kidney disease or liver disease. It should also be used carefully in dogs who are nursing, breeding, or pregnant.
Does cefpodoxime interact with other dog medications?
Cefpodoxime should be used with caution in dogs who also take:
Warfarin
Probenecid
Famotidine and other similar medications
Amphotericin B
Proton-pump inhibitors, like omeprazole or pantoprazole
Before your dog is prescribed cefpodoxime, tell your veterinarian which medications and supplements you give them.
What should you do if your dog misses a dose of cefpodoxime?
If you forget to give your dog a dose of cefpodoxime, give it again as soon as you remember. Then resume the regular dose schedule the next day. If you miss a day, skip the missed dose and resume the regular dose schedule. Never give 2 doses to catch up on missed doses.
The bottom line
Cefpodoxime (Simplicef, Vantin, Cefpoderm) is a prescription antibiotic that treats bacterial infections in dogs. It is most commonly used for certain skin infections and bacterial infections in other parts of the body. Cefpodoxime is most commonly given to dogs as a tablet and given once a day. Most dogs tolerate cefpodoxime well, but some have gastrointestinal side effects like vomiting or diarrhea.
Follow your veterinarian’s instructions for cefpodoxime. Call them if your dog has serious side effects.
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References
Brooks, W., et al. (2024). Cefpodoxime proxetil (Simplicef, Vantin). Veterinary Partner.
Mercer, M. A., et al. (2022). Cephalosporins and cephamycins use in animals. Merck Veterinary Manual.
Plumb’s Veterinary Medication Guides. (2020). Cefpodoxime.
Zoetis. (2014). Freedom of information summary: Supplemental new animal drug application.
Zoetis. (2020). Simplicef [package insert].
