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Pentamidine

Pentamidine Side Effects

Christina Aungst, PharmD, MWCAllison Gourley, PharmD
Reviewed by Christina Aungst, PharmD, MWC, Allison Gourley, PharmD
Last reviewed on May 2, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Cough during or right after inhaling [[EDITOR|DRUG_DISPLAY_NAME]] (38%)
  • Airway tightening during or right after inhaling [[EDITOR|DRUG_DISPLAY_NAME]] (15%)
  • Wheezing (1-5%)
  • Oral thrush (1-5%)
  • Bad taste in mouth (1-5%)
  • Headache (1-5%)
  • Chest pain (1-5%)
  • Respiratory infection (1-5%)

Less Common Side Effects

  • Night sweats
  • Diarrhea
  • Nausea
  • Herpes flare
  • Shingles
  • Flu-like symptoms

Pentamidine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • PCP infection: shortness of breath, fever, cough
  • Inflammation of the pancreas (pancreatitis): upper stomach pain, fever, nausea, vomiting, yellowing of the skin or eyes

Source: DailyMed

The following Pentamidine side effects have also been reported

Pentamidine may cause some serious side effects, including heart problems, low blood pressure, low or high blood sugar, and other blood problems. You and your doctor should discuss the good this medicine will do as well as the risks of receiving it.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Decrease in urination

sore throat and fever

unusual bleeding or bruising

Signs of diabetes mellitus or high blood sugar

Drowsiness

flushed, dry skin

fruit-like breath odor

increased thirst

increased urination

loss of appetite

Signs of low blood sugar

Anxiety

chills

cold sweats

cool, pale skin

headache

increased hunger

nausea

nervousness

shakiness

Signs of low blood pressure

Blurred vision

confusion

dizziness

fainting or lightheadedness

unusual tiredness or weakness

Less common

Fast or irregular pulse

fever

nausea and vomiting

pain in upper abdomen

pain, redness, and/or hardness at place of injection

skin rash, redness, or itching

Note: Signs of diabetes mellitus or high blood sugar, or signs of low blood sugar may also occur up to several months after you stop receiving this medicine.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

loss of appetite

nausea and vomiting

Stomach problems, such as nausea and vomiting, or loss of appetite, are common minor side effects seen in pentamidine treatment. However, if you have these problems, and at the same time have sharp pain in the upper abdomen, or an unusual decrease in the amount of urine, check with your doctor immediately.

Pentamidine may also cause an unpleasant metallic taste. This side effect is to be expected and does not require medical attention.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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