PAMIDRONATE treats high calcium levels in the blood caused by cancer. It may also be used with chemotherapy to treat weakened bones caused by cancer. It can also be used to treat Paget's disease of the bone. It works by slowing down the release of calcium from bones. This lowers calcium levels in your blood. It also makes your bones stronger and less likely to break (fracture). It belongs to a group of medications called bisphosphonates.