The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Numbness, tingling, or pricking feeling in the hands or feet (neuropathy; up to 82%)
- Low white blood cell count (up to 85%)
- Low platelet count (71%)
- Nausea (71%)
- Feeling very tired (70%)
- Diarrhea (56%)
- Vomiting (41%)
- Throat tingling or aching (38%)
- Mouth sores (38%)
- Low appetite (35%)
- Cough (35%)
- Constipation (32%)
- Stomach pain (29%)
- Anemia (27%)
Less Common Side Effects
- Muscle ache
- Headache
- General pain
- Shortness of breath
- Rash
- Swelling
- Fever
- Hair loss
- Weight loss
- Trouble sleeping
- Changes in vision
- Changes in taste
- Elevated liver enzyme levels
Note: Reported from studies with people who took [[EDITOR|DRUG_DISPLAY_NAME]] with fluorouracil and leucovorin for advanced colon cancer. These people didn’t have any previous treatment.
Oxaliplatin serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction: breathing problems; hives; rash; itchiness; swelling of the face, mouth, or lips
- Low blood cell counts: fever, chills, feeling very tired, unusual bleeding or bruising
- Serious bleeding: unusual bleeding, bleeding that’s difficult to stop, easy bruising, blood in urine or stool
- Abnormal heart rhythm: chest pounding, chest pain, trouble breathing, feeling faint or lightheaded
- Lung problems: cough, wheezing, trouble catching your breath
- Liver problems: pain in the right side of the stomach, yellowing of the eyes or skin
- Severe muscle damage: muscle weakness, pain, dark or brown urine
- Posterior reversible encephalopathy syndrome (PRES): headache, feeling sluggish or confused, vision loss, seizure
Source: DailyMed
The following Oxaliplatin side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Abnormal tongue sensation
black, tarry stools
bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
bleeding gums
blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
blood in the urine or stools
burning, prickling, itching, or tingling of the skin
chills
decreased urination
difficulty performing daily activities such as writing, buttoning, swallowing, or walking
difficulty with articulating words
difficulty with breathing
difficulty with moving
difficulty with swallowing
dizziness
fainting
increase in heart rate
jaw spasm
lightheadedness
lower back or side pain
muscle pain or stiffness
numbness or painful sensations
pain in the chest, groin, or legs, especially the calves
pain in the joints
painful or difficult urination
pale skin
pinpoint red spots on the skin
rapid breathing
sensation of pins and needles
sores, ulcers, or white spots on the lips or in the mouth
stabbing pain
sunken eyes
swelling
swelling or inflammation of the mouth
swollen glands
thirst
troubled breathing with exertion
unsteadiness or awkwardness
unusual bleeding or bruising
unusual tiredness or weakness
vision changes
wrinkled skin
Less common
Fast heartbeat
increased thirst
irregular heartbeat
loss of appetite
mood changes
nausea or vomiting
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
tightness in the chest
Incidence not known
Back, leg, or stomach pains
blindness
bloated stomach
blue-yellow color blindness
blurred vision
changes in patterns and rhythms of speech
dark urine
deafness
decreased vision
deep breathing
drowsiness
electric shock-like sensation that moves down the back and into the legs following a bending movement of the neck
general body swelling
increased urination
irregular heartbeat, recurrent
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of deep tendon reflexes
muscle cramps or spasms
muscle tremors
pain and fullness in the right upper abdomen or stomach
restlessness
severe constipation
severe diarrhea
severe nosebleeds
severe stomach cramps or tenderness
severe vomiting
trouble with speaking
twitches of the muscle visible under the skin
weakness of the muscles in your face
yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Acid or sour stomach
belching
body aches or pain
ear congestion
feeling unusually cold, shivering
headache
indigestion
loss of voice
stomach discomfort, upset, or pain
trouble sleeping
Less common
Bad, unusual, or unpleasant (after) taste
bloated or full feeling
bloody nose
burning while urinating
change in taste
congestion
cracked lips
dryness or soreness of the throat
excess air or gas in stomach or intestines
feeling of warmth
passing gas
rapid weight gain
redness of the face, neck, arms, and occasionally upper chest
tender, swollen glands in the neck
thinning of the hair
unusual tearing of the eyes
voice changes
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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