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Osmolex ER

Osmolex ER Side Effects

Ally Tsai, PharmDConnie Zheng, PharmD
Reviewed by Ally Tsai, PharmD, Connie Zheng, PharmD
Last reviewed on January 10, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Please note: These are common side effects reported by people who took amantadine immediate-release.

  • Nausea (5-10%)
  • Dizziness (5-10%)
  • Trouble sleeping (5-10%)

Less Common Side Effects

  • Depression, anxiety
  • Feeling irritated, agitated, or confused
  • Hallucinations
  • Strange dreams
  • Not feeling hungry
  • Dry mouth or dry nose
  • Constipation or diarrhea
  • Feeling tired
  • Headache
  • Livedo reticularis (web-like purple-blue skin discoloration)

Osmolex ER serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behaviors
  • Neuroleptic malignant syndrome (NMS): very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure
  • Accidentally taking too much (overdose): death, fast heartbeat, difficulty breathing, decreased urination, stiff or rigid arms or legs, confusion

Source: DailyMed

The following Osmolex ER side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bladder pain

bloody or cloudy urine

blurred vision

confusion

difficult, burning, or painful urination

dizziness or lightheadedness

fainting

falls

frequent urge to urinate

lower back or side pain

seeing, hearing, or feeling things that are not there

swelling of the hands, feet, or lower legs

Less common

Inability to move the eyes

increased blinking or spasms of the eyelid

muscle spasm

sticking out of the tongue

trouble breathing, speaking, or swallowing

uncontrolled twisting movements of the neck, trunk, arms, or legs

unusual facial expressions

Rare

Chills

decreased vision or any change in vision

difficulty in coordination

fever

increased blood pressure

increase in body movements

irritation and swelling of the eye

loss of memory

mental depression

seizures

severe mood or mental changes

skin rash

slurred speech

sore throat

thoughts of suicide or attempts at suicide

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Agitation

anxiety

difficulty concentrating

dry mouth

headache

irritability

loss of appetite

nausea

nervousness

nightmares

purplish red, net-like, or blotchy spots on the skin

trouble with sleeping

Less common

Blindness

blurred vision

constipation

decrease in sexual desire

decreased vision

diarrhea

drowsiness

dry eyes

dryness of the mouth, nose, and throat

false sense of well-being

joint swelling

unusual tiredness or weakness

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Ally Tsai, PharmD
Reviewed by:
Ally Tsai, PharmD
Ally Tsai, PharmD, is a medication therapy management (MTM) pharmacist with 6 years of experience. As an MTM pharmacist, she helps people with complex medication regimens get the best results by conducting comprehensive medication reviews.
Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.

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