The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Shortness of breath and chest tightness (13%)
- Upper respiratory tract infections (e.g., common cold, sore throat, stuffy nose, runny nose; up to 13%)
- Nausea (13%)
- Diarrhea (12%)
- Tiredness (9%)
- Rash (7%)
- Gas (7%)
- Flu or flu-like symptoms (5%)
Less Common Side Effects
- Irregular periods (menses) or more menstrual bleeding
- Higher blood pressure
Orkambi serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Liver damage: upper right stomach pain or discomfort, dark-colored urine, pale-colored stools, yellowing of the skin or eyes
Source: DailyMed
The following Orkambi side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Change in vision
- Increase in blood pressure
- Increased pressure around the brain—severe headache, blurry vision, change in vision, nausea, vomiting
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
- Shortness of breath or chest pain
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Diarrhea
- Gas
- Fatigue
- Headache
- Nausea
- Runny or stuffy nose
- Sore throat
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