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Saxagliptin

Saxagliptin Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on June 25, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Less Common Side Effects

  • Low blood sugar

Saxagliptin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Inflammation of the pancreas: upper belly pain, nausea, vomiting, fever, fast heartbeat, shortness of breath
  • Heart failure: trouble breathing; swelling in your legs, ankles, or feet; rapid weight gain
  • Severe allergic reaction: hives; trouble breathing; swelling of your face, lips, or tongue

Source: DailyMed

The following Saxagliptin side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Anxiety

bladder pain

bloating or swelling of the face, arms, hands, lower legs, or feet

bloody or cloudy urine

blurred vision

body aches or pain

chills

cold sweats

confusion

cool, pale skin

cough

depression

difficult, burning, or painful urination

difficulty with breathing

dizziness

ear congestion

fast heartbeat

fever

frequent urge to urinate

headache

increased hunger

loss of voice

lower back or side pain

nasal congestion

nausea

nightmares

rapid weight gain

runny nose

seizures

shakiness

slurred speech

sneezing

sore throat

tingling of the hands or feet

unusual tiredness or weakness

unusual weight gain or loss

Incidence not known

Chest pain

constipation

darkened urine

decreased urine output

difficulty with swallowing

dilated neck veins

extreme fatigue

flaking or peeling of the skin

hives or skin rash

indigestion

irregular breathing

irregular heartbeat

large, hard skin blisters

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of appetite

pains in the stomach, side, or abdomen, possibly radiating to the back

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

severe joint pain

swelling of face, fingers, feet, or lower leg

tightness in the chest

troubled breathing

vomiting

weight gain

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Diarrhea

pain or tenderness around the eyes and cheekbones

redness of the skin

weakness

welts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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