Octagam is an immunoglobulin (also known as antibody) used for treating certain conditions related to the immune system. It's given as an intravenous (IV) infusion and is available in two different strengths that treat different conditions. This medication can raise your risk of serious side effects, including blood clots and kidney problems.
Conditions where your immune system is missing or not working like it should:
Trouble fighting infections (primary humoral immunodeficiency or PI) - Octagam 5% only
Low platelets (chronic (long-term) immune thrombocytopenia or ITP) - Octagam 10% only
Inflammation of the muscles and skin (dermatomyositis or DM) - Octagam 10% only
Octagam is a replacement for immunoglobulin G (IgG). IgG is an antibody that your immune system makes to help protect against organisms like viruses, bacteria, and fungi.
Certain medical conditions can cause your immune system to be too active or too inactive. The exact way Octagam works to treat these medical conditions isn't fully known. It's thought to boost your immune system to help prevent infections. It also might help prevent an overly active immune system from attacking parts of your own body by mistake.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Octagam 5% works well for the treatment of PI.
Octagam 10% works well for chronic ITP and DM.
Octagam 5% can be used in children as young as 6 years old for PI.
Can be given at home by a provider, if approved
Needs to be given as an injection by a provider
Has a lot of potential risks, such as kidney and lung problems
Available as brand name only, which can be expensive
Mark your appointments on your calendar for when you need to see your provider and receive Octagam. This helps make sure you don't miss any doses. If you accidentally miss a dose, talk with your provider right away about rescheduling your appointment.
Bring a book or other activity to your infusion appointment to help pass the time.
Octagam can raise your risk of blood clots. Get medical help right away if you experience symptoms of a blood clot, including cough, difficulty breathing, chest pain, headache, trouble speaking, or weakness on one side of your body.
Octagam can raise your risk of kidney problems. Contact your provider right away if you experience symptoms of kidney problems, such as tiredness, trouble sleeping, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, or muscle cramps.
Before getting any vaccines, let your provider know you're receiving Octagam because it can interfere with your response to live vaccines (e.g., MMR (measles, mumps, and rubella vaccine)).
If you're receiving Octagam for PI (poor immune system), let your provider know right away if you've been exposed to measles or are planning to travel to places at high risk for measles. You might need additional doses of Octagam to help prevent infection or protect you against serious illness.
If your provider instructs you to have a supply of medication for your home infusion, you can store Octagam 10% in the refrigerator for 3 years (36 months) from the date it was manufactured, or at room temperature for 9 months. You can keep Octagam 5% at room temperature for 2 years (24 months) from the date it was manufactured. Don't put the medication in the freezer because this can damage it.
Octagam can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Older age | Not moving much or on bed rest | History of blood clots | Medical conditions that raise your risk of blood clots | Taking medications that contain estrogen | Central IV lines or other catheters in your veins | Have thick blood | History or risk of heart problems
Octagam can raise your risk of getting blood clots in various parts of your body. Symptoms of a blood clot might be different depending on the location of the clot. They can include swelling, warmth, or tenderness in the legs. But more seriously, clots can lead to breathing problems, heart attack, or stroke and cause chest pain; difficulty breathing; or weakness of the face, legs, or arms. Call 911 if you have any of these symptoms, because this is a medical emergency.
Risk factors: Older than 65 years | History of kidney problems | High blood sugar | Sepsis | Having high amounts of certain proteins in blood (paraproteinemia) | Not enough fluids in the body | Taking medications that can cause kidney damage
Octagam can cause severe, and even fatal, kidney problems. Your risk is higher if you have certain factors like older age, diabetes, or taking medications that can cause kidney problems. Your provider will order lab tests to check your kidney health before and during treatment with Octagam. If your kidney health worsens during treatment, your provider might slow down your infusion or even have you stop taking it. Contact your provider if you develop any signs or symptoms of kidney failure, including changes in your need to urinate, tiredness, dry and itchy skin, low appetite, and muscle cramps.
Risk factors: Allergy to corn
Serious allergic reactions, including life-threatening reactions like anaphylaxis (closing of the throat), are possible. Tell your provider all of your allergies before starting Octagam. This medication is made with a sugar from corn, so let them know if you have allergies to corn. If you notice a choking sensation, difficulty breathing, swelling of the lips or tongue, swelling around your eyes, sweating, dizziness, or nausea after using Octagam, get medical attention right away.
Risk factors: Type 1 or type 2 diabetes | Using insulin | Using glucose meters that use GDH-PQQ
Octagam contains maltose, which is a type of sugar. Maltose can cause your blood sugar readings to be falsely high if you use certain glucose monitors that use a substance called GDH-PQQ to detect blood sugar. This raises your risk for low blood sugar (hypoglycemia) if you give yourself insulin to correct this falsely high blood sugar level. Contact your local pharmacist or the manufacturer of the glucose monitor test you use if you're not sure if it can be used with products that have maltose in them.
Risk factors: Doses that are 2 grams/kg or higher | Blood type other than O
Octagam can cause your body to rapidly destroy your own red blood cells. Your provider will monitor your blood cell counts before and during treatment to help make sure they don't drop too low. Contact your provider if you experience symptoms such as fatigue, dizziness, and weakness.
Risk factors: Doses that are 2 grams/kg or higher | Medication infused too fast
Although rare, Octagam can cause inflammation of the brain (aseptic meningitis). It can start to happen within several hours to 2 days after receiving Octagam. Typically, it goes away within several days of stopping treatment. Contact your provider if you experience symptoms of meningitis, including severe headache, neck stiffness, sleepiness, fever, sensitivity to light, painful eye movements, nausea, or vomiting.
Octagam can cause a condition called transfusion-related acute lung injury (TRALI). This condition happens when fluid backs up in your lungs. It typically occurs within 1 to 6 hours after receiving the medication. Let your provider know right away if you experience symptoms of lung injury like severe breathing problems, chest pain or tightness, a racing heartbeat, or fever.
Because Octagam is made from human blood products, there's a risk that it might contain viruses that can make you sick. However, your risk of infection is low, since the donors of these blood products are carefully screened. Also, there are high manufacturing standards put into place to make sure the viruses are killed or removed. To prevent serious infections in the rare case that your doses of Octagam are affected, let your provider know immediately if you start to feel sick or have symptoms such as feeling confused and anxious, or having trouble maintaining your balance.
Your dose will depend on your body weight. During treatment, your provider will adjust the dose based on your response to the medication. In general:
Primary humoral immunodeficiency (Octagam 5%): The typical dose is 300 mg/kg to 600 mg/kg of body weight injected into the veins (IV) every 3 to 4 weeks. Your provider might give you extra doses if you're at risk of measles exposure (e.g., traveling) or if you were exposed to measles.
Chronic immune thrombocytopenia (Octagam 10%): The typical dose is 1 gram/kg of body weight IV once per day for 2 days.
Dermatomyositis (Octagam 10%): The typical dose is 2 grams/kg of body weight IV. This dose is split into equal doses and given over 2 to 5 days in a row each month.
Severe allergy to human immune globulin
Immunoglobulin A (IgA) deficiency with antibodies against IgA and a history of allergic reaction
Severe allergy to corn (Octagam 5% only)
Conditions where your immune system is missing or not working like it should:
Trouble fighting infections (primary humoral immunodeficiency or PI) - Octagam 5% only
Low platelets (chronic (long-term) immune thrombocytopenia or ITP) - Octagam 10% only
Inflammation of the muscles and skin (dermatomyositis or DM) - Octagam 10% only
Primary humoral immunodeficiency or PI in adults and children ages 2 years and older
Prevent bleeds during surgery in adults and children with immune thrombocytopenia (ITP)
Chronic inflammatory demyelinating polyneuropathy (CIDP) in adults
Primary humoral immunodeficiency (PI) in people ages 2 years and older
Chronic immune thrombocytopenia (ITP) in adults (to control and prevent bleeding)
Chronic inflammatory demyelinating polyneuropathy (CIDP) in adults (to improve muscle function)
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