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Nulojix

Nulojix Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on February 4, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Anemia (45%)
  • Diarrhea (39%)
  • Constipation (33%)
  • Urinary tract infection (37%)
  • Swelling in the arms, legs, or feet (34%)
  • High blood pressure (32%)
  • Fever (28%)
  • Cough (24%)
  • Vomiting (22%)
  • Headache (21%)

Less Common Side Effects

Nulojix serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Post-transplant lymphoproliferative disorder (PTLD): fever; night sweats; not feeling well; unplanned weight loss; lower appetite; swollen lymph node in the neck, armpit, or groin; unusual changes in mood or behavior; confusion; problems thinking; movement problems
  • Infection: fever, chills, muscle aches, change in appetite, vomiting, pain while urinating, weight loss, skin rash

Source: DailyMed

The following Nulojix side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Abdominal or stomach pain

agitation

black, tarry stools

bladder pain

bloating or swelling of the face, arms, hands, lower legs, or feet

bloody or cloudy urine

blurred vision

bone pain

burning while urinating

chest pain

chills

coma

confusion

convulsions

cough or hoarseness

decreased frequency or amount of urine

decreased urine output

depression

difficult or labored breathing

difficult, burning, or painful urination

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

dry mouth

fainting

fast or irregular heartbeat

fever

frequent urge to urinate

headache

hostility

inability to move the arms and legs

increased blood pressure

increased thirst

irritability

itching in other skin areas

lethargy

loss of appetite

loss of bladder control

lower back or side pain

mood or mental changes

muscle pain or cramps

muscle spasms (tetany) or twitching

nausea or vomiting

nervousness

numbness or tingling in the hands, feet, or lips

pale skin

pounding in the ears

rapid weight gain

scaling

shortness of breath

slow or fast heartbeat

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stupor

sudden decrease in the amount of urine

sudden numbness and weakness in the arms and legs

sweating

swelling of the face, ankles, or hands

swollen glands

tightness in the chest

trembling

troubled breathing

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

weakness or heaviness of the legs

weight gain

wheezing

Less common

Back pain

coughing or spitting up blood

drowsiness

joint pain, stiffness, or swelling

loss of appetite

night sweats

persistent non-healing sore

pink growth reddish patch or irritated area

shiny bump

sudden high fever or low-grade fever for months

swelling of the feet or lower legs

weight gain

white, yellow, or waxy scar-like area

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abdominal or stomach cramps

blemishes on the skin

body aches or pain

collection of blood under the skin

cough producing mucus

deep, dark purple bruise

diarrhea

difficulty having a bowel movement (stool)

difficulty with moving

dry mouth

ear congestion

flushed, dry skin

fruit-like breath odor

hair loss or thinning of the hair

increased hunger

increased sweating

increased urination

itching, pain, redness, or swelling

loss of consciousness

loss of voice

muscle cramps in the hands, arms, feet, legs, or face

muscle or bone pain

muscle pain or stiffness

numbness and tingling around the mouth, fingertips, or feet

pain in the joints

pimples

shakiness in the legs, arms, hands, or feet

shortness of breath

sleeplessness

sneezing

swelling or inflammation of the mouth

tightness in the chest

tremor

trouble sleeping

unable to sleep

unexplained weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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