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Noxafil

Noxafil Side Effects

Kristianne Hannemann, PharmDConnie Zheng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Connie Zheng, PharmD
Last reviewed on February 27, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (32%)
  • Low potassium levels (22%)
  • Fever (21%)
  • Nausea (19%)
  • Rash (15%)
  • Nose bleed (14%)
  • Headache (14%)
  • Stomach pain (13%)
  • Vomiting (12%)
  • Chills (12%)
  • Swelling in arms or legs (12%)

Note: The side effects listed above were reported by adults taking [[EDITOR|DRUG_DISPLAY_NAME]] for prevention of fungal infections.

Less Common Side Effects

  • Cough
  • High blood pressure
  • Poor appetite
  • Feeling tired
  • Constipation

Noxafil serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious liver problems: nausea, vomiting, stomach pain, yellowing of the skin or whites of the eyes, flu-like symptoms
  • Abnormal heart rhythm: irregular heartbeat, racing heart, chest pain, dizziness
  • Changes in electrolytes: nausea, vomiting, muscle cramps, muscle weakness, abnormal heartbeat, feeling tired

Source: DailyMed

The following Noxafil side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach pain

black, tarry stools

bloody nose

blurred vision

body aches or pain

confusion

cough

diarrhea

difficult or labored breathing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

fever or chills

fruit-like breath odor

heavy non-menstrual vaginal bleeding

increased thirst or urination

irregular heartbeats

loss of voice

muscle pain, spasms, or twitching

nausea or vomiting

numbness or tingling in the hands, feet, lips, mouth, or fingertips

painful cold sores or blisters on the lips, nose, eyes, or genitals

painful or difficult urination

pounding in the ears

slow or fast heartbeat

small red or purple spots on the skin

sores, ulcers, or white spots on the lips, tongue, or inside the mouth

sweating

tender, swollen glands in the neck

tightness in the chest

trembling

trouble swallowing

unexplained weight loss

yellow eyes or skin

Less common

Fainting

irregular heartbeat, recurrent

Incidence not known

Anxiety

change in mental status

chest pain or discomfort

darkening of the skin

itching or skin rash

mental depression

seizures

sudden shortness of breath or troubled breathing

swelling of the eyes or eyelids

swelling of the face, fingers, feet, or lower legs

weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

back pain

belching

difficulty having a bowel movement (stool)

heartburn

muscle stiffness

pain in the joints

trouble sleeping

Less common

Bad, unusual, or unpleasant (after) taste

change in taste

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.
Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.

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