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Chlorpheniramine/Phenylephrine

Chlorpheniramine/Phenylephrine Side Effects

Kristianne Hannemann, PharmDMichelle Nguyen, PharmD
Reviewed by Kristianne Hannemann, PharmD, Michelle Nguyen, PharmD
Last reviewed on February 16, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Excitability (especially in children)

Chlorpheniramine/Phenylephrine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, fever, confusion

Source: DailyMed

The following Chlorpheniramine/Phenylephrine side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart palpitations—rapid, pounding, or irregular heartbeat
  • Increase in blood pressure

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Anxiety, nervousness
  • Headache
  • Trouble sleeping
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