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Midazolam

Midazolam Side Effects

Hope Chang, PharmD, AAHIVPKristianne Hannemann, PharmD
Reviewed by Hope Chang, PharmD, AAHIVP, Kristianne Hannemann, PharmD
Last reviewed on April 27, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Oral syrup

  • Vomiting (8%)
  • Nausea (4%)

Injection for sedation

  • Pain at injection site (4-5%)
  • Hiccups (4%)
  • Nausea (3%)
  • Vomiting (3%)

Injection for long-lasting seizure

  • Upper airway blockage (5%)
  • Agitation (4%)
  • Fever (4%)
  • Confusion (3%)

Less Common Side Effects

  • Drowsiness
  • Headache
  • Coughing

Midazolam serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe difficulty breathing

Source: DailyMed

The following Midazolam side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Aggressiveness

agitation

anxiety

choking

confusion

decreased awareness or responsiveness

decreased urine output

difficulty walking, speaking, or writing

discouragement

dizziness

feeling sad or empty

fever

headache

irritability

lack of appetite

loss of bladder or bowel control

loss of consciousness

loss of interest or pleasure

memory loss

muscle twitching

nausea

nightmares or unusually vivid dreams

rapid weight gain

seizures

severe sleepiness

strong urge to urinate

swelling of the face, ankles, or hands

thirst

trouble concentrating

trouble sleeping

trouble breathing

unable to speak

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Lack of coordination

relaxed and calm feeling

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Rare

Muscle stiffness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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