Metformin ER is a biguanide used to treat type II diabetes. It helps control blood sugar in combination with diet and exercise. Metformin is widely considered the first-line treatment for adult onset diabetes because it rarely causes hypoglycemia and can help with weight loss. Brands include Fortamet and Glucophage XR. The immediate release version is available as generic metformin and Glucophage. Extended-release metformin combination pills include Janumet XR (Januvia and metformin) and Actoplus Met XR (pioglitazone and metformin).

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