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Melatonin

9 Medications That May Interact With Melatonin Supplements

Check with your healthcare provider if melatonin supplements are safe for you based on your health history and which medications you take.

Lauren Smith, MASanjai Sinha, MD
Written by Lauren Smith, MA | Reviewed by Sanjai Sinha, MD
Updated on September 17, 2025
Reviewed by Sanjai Sinha, MD | September 17, 2025

Melatonin supplements are a common product for helping people sleep. Many people believe supplements are natural and harmless, but there are still risks. In this video, learn about common medications that interact with melatonin supplements, such as by causing excessive drowsiness or reducing the effectiveness of your medications.

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Lauren Smith, MA
Written by:
Lauren Smith, MA
Lauren Smith, MA, has worked in health journalism since 2017. Before joining GoodRx, she was the senior health editor and writer for HealthiNation.
Sanjai Sinha, MD
Reviewed by:
Sanjai Sinha, MD
Sanjai Sinha, MD, is a board-certified physician with over 20 years of experience. He specializes in internal medicine.

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