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AMINOLEVULINIC ACID is a light sensitizing drug that is used in photodynamic therapy (PDT). PDT is used to treat many types of skin conditions including actinic keratosis and certain types of skin cancer. PDT is a two-step process that requires application of a drug and then exposure to a certain type of light. Compare medical supplies and devices.
Prescription Settings
1.5ml of 20%
1 applicator
1.5ml of 20%
1 applicator

What is Levulan?

Commonly Used Brand Name(s)Ameluz, Levulan Kerastick

Therapeutic ClassificationsPhotosensitizing Agent


Aminolevulinic acid gel is used in combination with photodynamic therapy (PDT) using the medical device, BF-RhodoLED® for the treatment of mild to moderate actinic keratoses on the face and scalp.

Aminolevulinic acid solution followed by exposure to a certain type of light (blue light using the BLU–U Blue Light Photodynamic Therapy Illuminator) is used to treat minimally to moderately thick actinic keratoses of the face, scalp, or arms.

This medicine is to be given only by or under the direct supervision of a health care provider.

Proper UseTOP

You will receive this medicine in a clinic or doctor's office. A nurse or other trained health professional will apply the medicine.

This medicine comes with a patient information leaflet and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any concerns.

If you are using the aminolevulinic acid solution:

  • This medicine is applied on your lesions. Do not get any of the solution into your eyes, nose, mouth, or ears.
  • After application of the solution to the arms, cover the treated area with a low density polyethylene plastic wrap held in place with an elastic net dressing.
  • Application of the solution to target lesions must be followed by blue light illumination treatment using BLU–U Blue Light Photodynamic Therapy Illuminator in your doctor's office after 3 hours for upper arm lesions or after 14 to 18 hours for face or scalp lesions.
  • Your doctor may want to retreat you after 8 weeks if your skin condition did not completely resolve.
  • Call your doctor if you cannot return for the blue light illumination treatment after the aminolevulinic acid solution application. You should then protect the treated skin from sunlight and prolonged or intense light for at least 40 hours.

If you are using the aminolevulinic acidgel:

  • This medicine is applied on your lesions or to the skin around the lesions. Do not get any of the gel into your eyes, nose, mouth, or ears. Rinse it off right away if it does get on these areas.
  • After gel application, the area where the gel has been applied will be covered with a light-blocking, occlusive dressing for 3 hours.
  • Immediately after removing the dressing and any remaining gel, you will be treated with a red light using the BF-RhodoLED® lamp.
  • If the lesions cannot be treated with the BF-RhodoLED® lamp within 3 hours after the gel has been applied, rinse off the gel with saline and water and protect the lesion sites from sunlight or prolonged or intense light for 2 days.
  • Your doctor may want to retreat you after 3 months if your skin condition did not completely resolve.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of aminolevulinic acid in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aminolevulinic acid in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical ProblemsTOP

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to porphyrins or
  • Allergy to soybean phosphatidylcholine or
  • Porphyria (enzyme problem) or
  • Skin sensitivity to sunlight—Should not be used in patients with these conditions.
  • Bleeding or blood clotting problems, inherited or acquired—Use with caution. May increase risk of bleeding in patients using Ameluz®.


Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

This medicine can cause episodes of temporary memory loss. Check with your doctor right away if you have problems with your memory, confusion, or disorientation.

For Ameluz® topical gel:

  • If your condition does not improve within 3 months, or if it becomes worse, check with your doctor.
  • Using Ameluz® with BF-RhodoLED® lamp may cause eye irritation or injury. It may also cause swelling of the eyelids. Tell your doctor right away if you have blurred vision, changes in vision, or red, sore eyes after receiving this medicine.

For Levulan® Kerastick® topical solution:

  • Avoid exposure to light if you experience stinging or burning on the treated areas before blue light treatment.
  • During the blue light treatment you will experience sensations of tingling, stinging, prickling or burning of the treated skin. These feelings of discomfort should improve at the end of the light treatment.
  • Following treatment, the actinic keratoses and possibly the surrounding skin will redden and swelling and scaling may also occur. These changes are temporary and should completely resolve after 4 weeks of treatment.

After aminolevulinic acid application, avoid exposure to sunlight or bright indoor light (eg, from examination lamps, operating room lamps, tanning beds, or being close to lights) up until the time of the blue or red light treatment. Wear long-sleeved shirts, gloves, or other protective clothing to shade the treated skin before blue light treatment. Wide-brimmed hats or similar head covering can help protect you from sunlight or sources of light. Sunscreens will not protect you from sunlight or sources of light.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

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