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Leqembi

Leqembi Side Effects

Kristianne Hannemann, PharmDCydnee Ng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Cydnee Ng, PharmD
Last reviewed on September 4, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Infusion-related reaction (26%)
  • Bleeding in the brain (14%)
  • Swelling or fluid buildup in the brain (13%)
  • Headache (11%)

Less Common Side Effects

Leqembi serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Problems in the brain: headache, confusion, dizziness, vision changes, trouble communicating, weakness, trouble walking, nausea, seizure
  • Infusion-related reaction: trouble breathing, dizziness, fever, chills, body aches, joint pain, pounding chest, nausea, vomiting
  • Severe allergic reaction: swelling in the face or throat, tightening of the throat, chest tightness, trouble breathing
When do Leqembi possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Risk of bleeding in the brain
Risk of swelling in the brain
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: FDA

The following Leqembi side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Headache, worsening confusion, dizziness, change in vision, nausea, seizures
  • Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

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