The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
RA:
- Injection-site reactions (71%)
- Sore throat, runny nose, and other symptoms of an infection (up to 39%)
- Headache (12%)
- Nausea (8%)
- Diarrhea (7%)
NOMID:
- Injection-site reactions (16%)
- Headache (14%)
- Vomiting (14%)
- Joint stiffness (12%)
- Fever (12%)
- Runny nose and sore throat (12%)
Please note: The safety profile of Kineret (anakinra) in people treated for DIRA is similar to that of for NOMID.
Less Common Side Effects
RA:
- Joint stiffness
- Chills, body aches, and other flu-like symptoms
- Stomach pain
NOMID:
- Cough, congestion, and other symptoms of an upper respiratory tract infection
- Rash
Kineret serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious infections: fever, tiredness, chills, cough, trouble breathing
- Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
Source: DailyMed
The following Kineret side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
fever or chills
headache
itching, pain, redness, swelling, tenderness or warmth on the skin
joint pain
muscle aches and pains
nausea or vomiting
stomach pain
Less common
Difficulty with swallowing
swelling of the face or lips
unusual bruising or bleeding
unusual tiredness or weakness
Incidence not known
Black, tarry stools
bleeding gums
blood in the urine or stools
dizziness
fast heartbeat
hives or welts
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
difficulty with moving
headache
muscle aches or stiffness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

