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Kesimpta

ofatumumab
Used for Multiple Sclerosis
Used for Multiple Sclerosis

Kesimpta (ofatumumab) is an injectable medication for adults with relapsing forms of multiple sclerosis (MS). It works as a monoclonal antibody to help lessen MS flare-ups that come and go. Kesimpta (ofatumumab) is injected under the skin. You can use the Kesimpta prefilled syringes or Sensoready Pens to inject. After the first 3 weekly injections, you inject the medication once a month. Some common side effects include a higher risk of infections, pain or swelling at the injection site, and headache.

Last reviewed on August 18, 2025
basics-icon

What is Kesimpta (ofatumumab)?

What is Kesimpta (ofatumumab) used for?

How Kesimpta (ofatumumab) works

Kesimpta (ofatumumab) is a monoclonal antibody. It's not exactly known how the medication works to help with MS.

But researchers think it attaches to a protein called CD20 found on immune cells in the body. It destroys these immune cells so they can't attack the coverings on your nerve cells by mistake. This might help relieve symptoms of MS.

Are you looking for information on Arzerra (ofatumumab) for chronic lymphocytic leukemia instead?
When does Kesimpta (ofatumumab) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsKesimpta
Drug ClassMonoclonal antibody
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Kesimpta (ofatumumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Back pain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infection: fever, tiredness, weakness, chills, cough, trouble breathing, confusion
  • Allergic reaction: anaphylaxis, swelling of the face or mouth, swollen throat, throat tightness, throat irritation, rash, hives, dizziness, trouble breathing
When do Kesimpta (ofatumumab) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Local injection site reactions

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Dizziness, loss of balance or coordination, confusion or trouble speaking
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Injection reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Kesimpta (ofatumumab)

thumbs-up

Pros

Injections are once a month (after the first 3 injections)

Can inject at home after you're trained

Comes as prefilled syringes and Sensoready Pens

Can be kept at room temperature for up to 7 days

thumbs-down

Cons

Must give as an injection under the skin

Raises your risk of infections

Not recommended for people who are pregnant

pharmacist-tips

Pharmacist tips for Kesimpta (ofatumumab)

pharmacist
  • Put a reminder on your calendar for your Kesimpta (ofatumumab) injections. This helps you stay on track with your treatment. Inject the medication once a week for 3 weeks. Skip a week. Then, inject the medication once a month.

    • If you miss a dose of Kesimpta (ofatumumab), inject the medication as soon as you remember. Afterwards, continue with your usual dosing schedule.

      • After you inject Kesimpta (ofatumumab), the area might get red, itchy, swollen, or sore. These reactions happen within hours after the injection. They're usually mild and go away in a couple days. You can hold an ice pack wrapped in a towel over the area for about 10 minutes if you need relief. Talk to your care team if you need more help, if these reactions get worse over time, or if they don't go away.

        • Call your care team if you think you've gotten sick while taking Kesimpta (ofatumumab). Look for signs like a fever, chills, a cough that doesn't go away, or pain when you urinate. Your care team can see if you need to get treated for the infection. They might tell you to wait until you're better before your next injection.

          • If you can get pregnant, use birth control while taking Kesimpta (ofatumumab) and for at least 6 months after your last injection. There's a chance that the medication could harm an unborn baby. Let your prescriber know if you become pregnant while taking Kesimpta (ofatumumab).

            How to use Kesimpta (ofatumumab):

            • Your first injection of Kesimpta (ofatumumab) will be given at your prescriber's office. Your care team will make sure you can inject the medication properly before they let you do it on your own at home. They'll also watch for reactions like headache, fever, muscle aches, and chills. These reactions are most common within a day of your first injection.

              • Follow the instructions on how to use and inject Kesimpta (ofatumumab) with the prefilled syringe or Sensoready Pen. Ask your care team or pharmacist if you have any questions or if you're not sure.

                • How to store Kesimpta (ofatumumab): Store the medication in the refrigerator, but don't let it freeze. If needed, you can keep it at room temperature (up to 86ºF) for up to 7 days before you need to throw it away. You can put unused Kesimpta (ofatumumab) back in the fridge but it's only good for another 7 days. Always keep the medication in the original package to protect it from light.

                  • When it's time for your Kesimpta (ofatumumab) injection: Take the medication out of the refrigerator and lay it on a flat surface. Let it warm up to room temperature for 15 to 30 minutes. Don't try to warm up the medication any other way, like with a microwave or under hot water; you might damage it. Always check that the liquid is clear or slightly brownish-yellow. If it's very cloudy, discolored, or has many particles, don't use it and get a new syringe or pen.

                    • Where to inject Kesimpta (ofatumumab): Inject the medication under the skin of your lower stomach (2 inches away from the belly button). You can also inject into the front of your thighs (preferred for the pen). Or, someone else can help inject it into your outer upper arm. Choose a different spot to inject into for each injection. Don't inject into skin with moles, scars, or stretch marks. Also avoid tender, bruised, red, scaly, or hard skin. This helps lower the risk of skin damage or irritation.

                      • How to inject with the Kesimpta SensoReady Pen: Use the pen within 5 minutes after taking off the cap (don't recap it). Hold and press the pen 90 degrees straight against the injection area. You'll hear a click when the injection starts and another click when it's almost done. Keep holding the pen against your skin until the window on it turns green all the way. Then, take the pen off your skin.

                        • How to inject with the Kesimpta prefilled syringe: Carefully take off the needle cap from the syringe. With one hand, pinch the skin at the injection site. With your other hand, insert the needle all the way into the skin at a 45-degree angle. Then, use the finger grips to hold the syringe and slowly press the plunger all the way down. Keep pressing the plunger down and hold the syringe in place for 5 seconds. Then, slowly release the plunger until the needle gets covered by the shield.

                          • How to throw away Kesimpta (ofatumumab) after each injection: Throw away used syringes and pens in a sharps container. You can also use something made of heavy-duty plastic, like a laundry detergent bottle. This helps keep you and others safe from getting hurt from needles. Don't throw them away in your trash can. Ask your pharmacist to learn more about how to get rid of your sharps.

                            More on Kesimpta (ofatumumab) tips

                            faqs

                            Frequently asked questions about Kesimpta (ofatumumab)

                            What is relapsing multiple sclerosis (MS)?
                            Relapsing multiple sclerosis (MS), also called relapsing-remitting MS, is the most common type of MS. People have attacks where they could have new MS symptoms or have MS symptoms that get worse. These can include blurry vision, dizziness, numbness, and weakness. The attacks can last from a day to a few weeks. Over time, attacks can happen more often and be harder to recover from. This can lead to a more serious form of MS called secondary progressive MS. Talk to your prescriber or neurologist if you have questions about MS.
                            Is Kesimpta (ofatumumab) chemotherapy?
                            No, Kesimpta (ofatumumab) isn't chemotherapy. Chemotherapy works by killing fast-growing cells in the body. It's usually used to treat cancer. But Kesimpta (ofatumumab) is a type of medication called a monoclonal antibody. It treats certain types of multiple sclerosis (MS). It works by stopping your immune cells from attacking the protective covering of your nerves.
                            How long does it take for Kesimpta (ofatumumab) to work?
                            In studies, Kesimpta (ofatumumab) generally slowed MS from getting worse over a few to several months. This was compared to another MS medication called Aubagio (teriflunomide). Remember, everyone can respond to medications in a different way. So, check in with your prescriber often about how Kesimpta (ofatumumab) is helping with your MS. Talk to them if you have questions about how long it takes for Kesimpta (ofatumumab) to work.
                            How long does Kesimpta (ofatumumab) stay in your system?
                            It takes a little under 3 months for most of Kesimpta (ofatumumab) to leave your body. This time frame is estimated from the medication's half-life. The half-life measures how much time it takes for half the amount of the medication to leave the body. If you have questions about how long Kesimpta (ofatumumab) stays in your system, talk to your prescriber.
                            Does Kesimpta (ofatumumab) cause weight gain?
                            People who took Kesimpta (ofatumumab) didn't report gaining weight. Talk to your primary care provider or prescriber if you have any changes in weight that worry you. They can help you figure out what might be the reason and ways to manage your weight.
                            Does Kesimpta (ofatumumab) cause diarrhea?
                            It's not common to have diarrhea from Kesimpta (ofatumumab). If diarrhea happens, be sure to rehydrate with fluids. Talk to your prescriber or primary care provider if you have diarrhea and don't know what might be the reason. Also talk to them if it bothers you a lot. They can help find out why it's happening and recommend over-the-counter medications to help.
                            How long can Kesimpta (ofatumumab) be out of the fridge?
                            If you need to, you can leave Kesimpta (ofatumumab) out of the refrigerator for up to 7 days. But make sure it doesn't get hotter than 86 degrees Fahrenheit. If it gets hotter than that, or if it's been out for more than 7 days, throw the medication away in a sharps container.
                            Where do you inject Kesimpta (ofatumumab)?
                            There are certain places you can inject Kesimpta (ofatumumab) under the skin. You can inject into the lower stomach, 2 inches from the belly button. You can also inject into the front of your thigh (this is preferred for the Kesimpta Sensoready Pen). Or, someone else can give you the injection into your outer upper arm. Never inject the medication into skin that's tender, bruised, red, scaly, or hard. Also, don't inject into moles, scars, or stretch marks. Talk to your care team if you're not sure where you can inject Kesimpta (ofatumumab).
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                            warings-icon

                            What are the risks and warnings for Kesimpta (ofatumumab)?

                            Kesimpta (ofatumumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                            risk-warning

                            Risk of infections

                            • Risk factors: Active, chronic (long-term), or recurrent infection | Other medical conditions that raise your risk of infection | Taking medications that weaken your immune system

                              Kesimpta (ofatumumab) can make it harder for your body to fight germs. This can raise your risk of getting bacterial, viral, or fungal infections. These infections can sometimes be serious or life-threatening.

                              Before you start Kesimpta (ofatumumab), talk to your prescriber about your medical history. They will check to see if you have hepatitis B. People with this infection have had serious problems while taking Kesimpta (ofatumumab). Your prescriber can check that this medication is safe for you.

                              Also let your care team know about all the medications you take. It's important to check if you take other medications that can make your immune system weaker. This can raise your risk of infections even higher.

                              Upper respiratory infections and urinary tract infections are common with Kesimpta (ofatumumab). Call your care team if you think you have an infection. Watch for a fever, chills, a cough, trouble breathing, weakness, and pain when you urinate. If you get sick, your prescriber might tell you to wait until you're better before you continue with your injections.

                              risk-warning

                              Injection reactions

                              The Kesimpta (ofatumumab) injection can cause reactions like fever, headache, muscle pain, and chills. Other reactions are itchiness, throat irritation, trouble breathing, dizziness, and fast heart rate. They usually happen within a day of your first injection. But they can also happen after later ones.

                              Sometimes, these reactions are hard to tell apart from a real allergic reaction. To keep you safe, your care team will help you with your first injection at the medical office or clinic. This is so you can get help fast if the reaction is serious.

                              If you have any of these symptoms at home, get medical help right away.

                              risk-warning

                              Lower antibody levels

                              Kesimpta (ofatumumab) can lower the levels of certain immunoglobulins (antibodies) in your body. Your prescriber will check your antibody levels with blood tests before and during treatment. They'll keep checking even after you stop until your levels are back to normal. If your antibody levels are too low, immunoglobulin infusions might help bring them up. Your care team can help decide what the next steps are if this happens.

                              risk-warning

                              Harm to an unborn baby

                              Animal studies show that Kesimpta (ofatumumab) can harm an unborn baby if given during pregnancy. It also has potential to make antibodies not work as well in newborns.

                              If you can become pregnant, use birth control while using Kesimpta (ofatumumab). Continue birth control for at least 6 months after your last dose of Kesimpta (ofatumumab). If you're pregnant or planning to be, ask your prescriber about safer options for you and your baby. Tell your prescriber right away if you get pregnant.

                              dosage

                              Kesimpta (ofatumumab) dosage forms

                              Typical dosing for Kesimpta (ofatumumab)

                              The typical starting dose is 20 mg injected under the skin once a week for 3 weeks.

                              Then starting from week 4, the typical maintenance dose is 20 mg injected under the skin once a month.

                              Inject Kesimpta (ofatumumab) under the skin of your lower stomach or front of your thigh. Someone can also help inject it into your outer upper arm.

                              More on Kesimpta (ofatumumab) dosage forms

                              contraindications-icon

                              Kesimpta (ofatumumab) contraindications

                              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Kesimpta (ofatumumab) will not be safe for you to take.
                              alternatives

                              What are alternatives to Kesimpta (ofatumumab)?

                              There are a number of medications that your doctor can prescribe in place of Kesimpta (ofatumumab). Compare a few possible alternatives below.
                              Used for:
                              • Relapsing forms of multiple sclerosis

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                              yellow - Kesimpta Prefilled Pen 20mg / 0.4mL Solution for Injection
                              This medicine is Yellow Pen.yellow - Kesimpta Prefilled Pen 20mg / 0.4mL Solution for Injection

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                              References

                              Best studies we found

                              American Cancer Society. (2025). Chemotherapy.

                              Gärtner, J., et al. (2022). Efficacy and safety of ofatumumab in recently diagnosed, treatment-naive patients with multiple sclerosis: Results from ASCLEPIOS I and II. Multiple Sclerosis.

                              Gohil, K. (2015). Multiple sclerosis: Progress, but no cure. Pharmacy and Therapeutics.

                              View All References (6)

                              Kang, C., et al. (2021). Ofatumumab: A review in relapsing forms of multiple sclerosis. Drugs.

                              MedlinePlus. (2025). Immunoglobulins blood test.

                              National Multiple Sclerosis Society. (n.d.). Types of MS.

                              Nelson, F. (2012). Relapsing and progressive multiple sclerosis: Understanding the differences. Practical Neurology.

                              Novartis Pharmaceuticals Corporation. (2025). Kesimpta- ofatumumab injection, solution [package insert]. DailyMed.

                              U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.

                              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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