Kesimpta Dosage for Multiple Sclerosis: Your GoodRx Guide

If you’re living with relapsing forms of multiple sclerosis (MS), Kesimpta (ofatumumab) is one treatment option your healthcare team may consider prescribing. Kesimpta offers the convenience of being able to administer your doses at home. You can also choose between a prefilled syringe or injector pen, whichever best suits your needs.

When you start Kesimpta, you’ll be given dosing instructions for you or a caregiver to follow. But if you need a refresher on Kesimpta dosages, or have questions about missing your dose, we cover this information and more below.

Kesimpta dosage forms

Kesimpta comes in two forms — a prefilled syringe and a Sensoready Pen. Both products deliver the same Kesimpta dose in the convenience of your own home. You and your healthcare team will decide the best option for you based on your medical history and preferences. 

Prefilled syringes

• Simple and familiar: Syringes are a familiar injection method for many people. They offer precise control and require minimal assembly.

• May require dexterity: Injecting the syringe might be challenging for people with limited hand strength or coordination.

• Portable and discreet: Syringes are compact and easily fit in a purse or backpack for on-the-go injections.

Sensoready Pens:

• Easy and intuitive: The Sensoready Pen clicks and injects automatically when you press it firmly against the skin, removing the need to manually push the plunger.

• No visible needle: The needle is inside the Sensoready Pen, where you can’t see it. This may be preferred if needles make you uncomfortable.

• Confidence booster: The click-and-inject mechanism provides audible and visual confirmation of a successful injection.

No matter which Kesimpta form you receive, they’re both stored the same way. Prior to use, you should store your Kesimpta injections in the refrigerator (between 36°F to 46°F) in their original container to protect them from light. Don’t place Kesimpta in the freezer or shake it at any point. 

If needed, you may store Kesimpta for up to 7 days at room temperature (up to 86°F). If you haven’t used Kesimpta stored this way within the 7 days, return it to the refrigerator. If you don’t use it within another 7 days, throw it away. To help you remember when to use it, write the date you removed Kesimpta from the fridge in the space provided on the box.

What’s the typical Kesimpta dosage?

Kesimpta prefilled syringes and Sensoready Pens both come in 20 mg doses. You’ll inject Kesimpta more frequently during the first 3 weeks of treatment before you start injecting it once a month.

• Week 1: Inject 20 mg dose

• Week 2: Inject 20 mg dose 

• Week 3: Inject 20 mg dose

• Week 4: Skip the injection

• Week 5 and once monthly thereafter: Inject 20 mg dose

Before injecting Kesimpta, remove it from the fridge about 15 to 30 minutes before your dose. This will help make your injection more comfortable, since cold injections can be more painful. Don’t remove the prefilled syringe needle cover or injection pen cap until you’re ready to use it.

What happens if you miss a dose of Kesimpta?

Kesimpta’s once-monthly dosing can make it a convenient option. But, now and again, you may find that you’ve missed a dose. What you should do next depends on whether you missed a weekly starter dose or monthly maintenance dose.

• Weekly dose: If you miss a Kesimpta dose in the first 3 weeks of starting the medication, contact your prescriber for when to take your next dose. 

• Monthly dose: If you miss a once-monthly injection, administer it as soon as possible, even if it's close to your next scheduled dose. The day you inject your missed dose will become your new monthly injection day. Inject your next dose 1 month later. Don’t attempt to double up on doses to make up for doses you’ve missed.

If it’s difficult to stay on track with your Kesimpta injections, it may be helpful to set alarms or use a medication reminder app. Your pharmacist is also a helpful resource for ways to help you administer your medication on time.

What should you do if you inject too much Kesimpta?

Each Kesimpta syringe and injection pen only contain one dose. So, it’s unlikely that you’ll inject too much, unless you double up on doses. But if you accidentally inject too much, you should contact your healthcare team or Poison Control at 1-800-222-1222 for guidance. Based on your situation, they can tell you if you’ll need to take any action.

How to save on Kesimpta

Kesimpta is a brand-name specialty medication, which means you’ll likely receive it from a specialty pharmacy. The pharmacy staff will typically work with your insurance plan regarding coverage and identify potential savings opportunities for you.

Kesimpta’s manufacturer also offers a free support program called Alongside. If you’re eligible, you may be able to access Kesimpta for as little as $0 through the program.

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Written by:

Zuri C. Hawkins-Jarrett, PharmD, MPH, BCPS

Zuri Hawkins-Jarrett graduated with her doctorate in pharmacy from The University of Georgia College of Pharmacy. She completed her residency training with Piedmont Columbus Regional in ambulatory care.

Edited by:

Alyssa Billingsley, PharmD

Alyssa Billingsley, PharmD, is the director of pharmacy content for GoodRx. She has over a decade of experience as a pharmacist and has worked in clinical, academic, and administrative roles.

Reviewed by:

Joshua Murdock, PharmD, BCBBS

Joshua Murdock, PharmD, BCBBS, is a licensed pharmacist in Arizona, Colorado, and Rhode Island. He has worked in the pharmacy industry for more than 10 years and currently serves as a pharmacy editor for GoodRx.

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