Jynneos
Jynneos is a vaccine that helps lower your risk of getting smallpox and monkeypox infections. This vaccine is only approved by the FDA for adults 18 years and older who are at high risk for these infections. If you're looking to find this vaccine, use our monkeypox vaccine finder.
What is Jynneos?
What is Jynneos used for?
Prevention of smallpox and monkeypox in adults
How Jynneos works
Jynneos is a live-attenuated vaccine, meaning it contains a weakened version of the vaccinia virus. The vaccine helps your body's immune system make antibodies against the monkeypox and smallpox viruses, which will attack the viruses if they ever infect your body.
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What are the side effects of Jynneos?
Common Side Effects
- Pain at injection site (up to 85%)
- Redness at injection site (up to 81%)
- Hard lump at injection site (up to 70%)
- Swelling at injection site (up to 67%)
- Itching at injection site (up to 43%)
- Muscle pain (up to 43%)
- Headache (up to 35%)
- Feeling tired (up to 34%)
Other Side Effects
- Nausea
- Chills
- Fever
Serious Side Effects
- Severe allergic reaction: hives, trouble breathing, swelling of the face, lips, tongue, or throat
Source: DailyMed
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Feeling faint or lightheaded
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Chills
- General discomfort and fatigue
- Headache
- Itching
- Muscle pain
- Nausea
- Pain, redness, or irritation at injection site
Pros and cons of Jynneos
Pros
Protects against multiple orthopoxviruses, including smallpox and monkeypox
People who've received smallpox vaccine in the past might only need one dose.
Can typically be given with other vaccines
Cons
Not studied in children
Only available as an injection, which can be painful
Must be given by a healthcare provider at an office, clinic, or pharmacy
Pharmacist tips for Jynneos
Read the vaccine information statement for more information on Jynneos.
Make sure to keep a record of all your immunizations and show it to your provider or pharmacist before receiving any vaccine, including Jynneos, to make sure you're receiving all your vaccines on schedule.
Allow extra time for your Jynneos vaccine appointment if you've had a severe allergic reaction to gentamicin, ciprofloxacin (Cipro), chicken, or eggs in the past. Your provider will monitor you for at least 30 minutes after your vaccine.
After your first dose of Jynneos, make sure to schedule your second dose. In order for this vaccine to work well, you need two doses, typically given 4 weeks apart. Let your provider know if you've received a smallpox vaccine in the past, since in this case you might only need one dose of Jynneos.
If you miss your second dose, it's recommended to get it as soon as possible. In most cases, you won't need to restart the series or get additional doses.
You're considered fully vaccinated against the monkeypox 2 weeks after your second dose of Jynneos. If possible, avoid activities that can put you at risk for monkeypox until that time.
If you get a severe reaction to Jynneos, you or your provider can report it to the vaccine adverse event reporting system (VAERS) website or by calling 1-800-822-7967.
Frequently asked questions about Jynneos
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What are the risks and warnings for Jynneos?
Jynneos can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Severe allergic reaction
Risk factors: History of allergy to gentamicin, ciprofloxacin (Cipro), chicken, or egg
As with any vaccine, there's a rare chance Jynneos can cause a life-threatening allergic reaction, like anaphylaxis. Let your provider know if you have a history of an allergic reaction to gentamicin, ciprofloxacin, chicken, or eggs, since Jynneos might contain these in small amounts. If so, they'll monitor you for 30 minutes after you get your vaccine so they can give you medical care if you do have a reaction. If you experience hives, trouble breathing, or swelling in your face or throat, get medical help right away.
Might not prevent monkeypox or smallpox
Risk factors: Weakened immune system
Vaccination with Jynneos doesn't guarantee you won't get smallpox or monkeypox. If you have a weakened immune system from certain medical conditions or medications (e.g., transplant or cancer medications), you might have a lower response to Jynneos. This means the vaccine might not work as well to protect you from getting infected. Avoid contact with those who are infected with smallpox or monkeypox. If someone close to you is infected, avoid sex, kissing, and touching their bodies (especially a rash). If possible, avoid activities that might put you at risk of being exposed until 2 weeks after your second dose of Jynneos.
Jynneos dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.5ml | 1 vial | $272.68 | $272.68 |
Typical dosing for Jynneos
Jynneos is given as a 2-dose series. The typical dose is one injection given under the skin by a healthcare provider. The second dose is given 4 weeks later.
How much does Jynneos cost?
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