Jentadueto, Jentadueto XR

Metformin in Jentadueto (linagliptin / metformin) can cause a rare, but serious medical condition called lactic acidosis (too much lactic acid in your blood). If left untreated, this condition can lead to other health problems, including organ failure, which can be deadly. Discuss with your primary care provider about your medical history before starting Jentadueto (linagliptin / metformin) and any planned procedures during treatment. They can check for your risk for lactic acidosis. Get medical attention immediately if you experience trouble breathing, irregular heartbeat, muscle pain, belly pain, or feeling very tired or dizzy. These can be signs that you have too much lactic acid in your blood.

Though rare, people who took linagliptin in clinical studies have reported having inflammation of the pancreas (pancreatitis). It's not known if Jentadueto (linagliptin / metformin) can raise your risk of pancreatitis if you've had this problem before. Some common symptoms of an inflamed pancreas are upper stomach pain, fever, nausea, and vomiting. If you start to feel any of these symptoms, contact your provider right away. You might need to stop taking Jentadueto (linagliptin / metformin).

If you've recently had a heart or kidney problem, let your provider know before starting Jentadueto (linagliptin / metformin). Though rare, people who took medications similar to linagliptin have developed heart failure. But it's unclear whether Jentadueto (linagliptin / metformin) carries this same risk and more research is needed in this area. Let your provider know right away if you experience any symptoms of heart failure, such as trouble breathing, tiredness, swelling in your body, or sudden weight gain. Your provider might recommend that you go to the hospital and that you stop taking Jentadueto (linagliptin / metformin).

Jentadueto (linagliptin / metformin) might cause serious allergic reactions, such as rash, peeling or blistering skin, swelling, trouble breathing, and dizziness. Let your provider know if you've had an allergic reaction to other DPP-4 inhibitors or "gliptins", such as Januvia (sitagliptin) or Tradjenta (linagliptin). Though unclear, it's possible that taking Jentadueto (linagliptin / metformin) might cause you to have another allergic reaction. If you experience an allergic reaction to Jentadueto (linagliptin / metformin), stop the medication and get medical care right away.

Taking diabetes medications that contain metformin, including Jentadueto (linagliptin / metformin), for a long period of time can cause your vitamin B12 levels to drop. Having low vitamin B12 levels can lead to a higher risk of anemia. Your provider will check your vitamin B12 levels through blood work every 2 to 3 years. If needed, your provider might recommend that you take vitamin B12 supplementation. Let your provider know if you frequently have low energy, dizziness, muscle problems, or tingling or numbness in your hands and feet.

People who take diabetic medications similar to linagliptin in Jentadueto (linagliptin / metformin) have experienced severe joint pain. This can happen anytime from a day to many years after starting the medication. For most people, the pain goes away after they stop the medication. If you experience any discomfort in your joints, speak to your provider right away.