Key takeaways:
Ingrezza (valbenazine) is a medication that treats movement disorders related to tardive dyskinesia and Huntington’s disease. The typical Ingrezza dosage is 80 mg once daily.
In most cases, you’ll start taking 40 mg of Ingrezza daily and work your way up to 80 mg over 1 to 2 weeks. Ingrezza comes in a capsule you can swallow whole as well as a sprinkle capsule you can open and mix into soft food.
You may need a lower Ingrezza dosage if you’re living with liver problems, have certain genetic differences, or take a medication that interacts with it. Your prescriber will help you find the right Ingrezza dosage for your needs.
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Ingrezza (valbenazine) is a medication that treats movement disorders related to tardive dyskinesia and Huntington’s disease. It works by lowering the levels of certain brain chemicals that affect movement.
Ingrezza comes in 40 mg, 60 mg, and 80 mg capsules and sprinkle capsules. Understanding your Ingrezza dosage and how to take it can help you get the most from your medication. This article reviews the typical FDA-approved dosages for Ingrezza as well as what to do if you miss a dose. But always follow your prescriber’s instructions, even if they differ from what’s listed here.
What’s the typical Ingrezza dosage for adults?
The recommended Ingrezza dosage depends on what condition you’re treating.
Tardive dyskinesia
The recommended Ingrezza dosage for tardive dyskinesia is 80 mg once daily. In most cases, you’ll start taking 40 mg daily then increase to 80 mg daily after 1 week.
If you’re unable to take 80 mg of Ingrezza due to side effects or other issues, you may take a lower dosage of 40 mg or 60 mg per day.
Huntington’s disease chorea
For Huntington’s disease-related chorea, a type of involuntary movement, the recommended Ingrezza dosage is 80 mg once daily. In most cases, you’ll start taking 40 mg once daily, then increase the dosage by 20 mg every 2 weeks until you reach the recommended dosage.
If you’re unable to take 80 mg of Ingrezza due to side effects or other issues, you may take a lower dosage of 40 mg or 60 mg per day.
Are there any dosage adjustments for medical conditions?
You may need a lower Ingrezza dosage if you’re living with certain health conditions, take medications that interact with it, or have certain genetic differences.
Liver problems
If you’re living with moderate to severe liver problems, the recommended Ingrezza dosage is 40 mg once daily. This is because Ingrezza is removed from your body by your liver. Liver problems can slow this process, which can lead to higher Ingrezza levels in the body. So a lower dosage helps keep Ingrezza levels within a safe range.
Medication interactions
Some drug interactions can also raise Ingrezza levels in your body. Medications can affect how Ingrezza is processed in your body. A lower Ingrezza dosage of 40 mg daily is recommended if you take it with medications such as:
Fluoxetine (Prozac)
Paroxetine (Paxil)
Oral ketoconazole
Clarithromycin (Biaxin)
Be sure to review your updated list of medications and supplements you take with your healthcare team before starting Ingrezza. They can look for any potential interactions and adjust your dosage if needed.
Genetic differences
Some people naturally process certain medications more slowly due to genetic differences. This is often referred to as being a “poor metabolizer.” If you’re considered a poor metabolizer of CYP2D6, a liver enzyme that breaks down Ingrezza, the recommended dosage is 40 mg once daily. Your prescriber will let you know if this applies to you.
How to take Ingrezza
You should swallow Ingrezza capsules whole, with or without food. You can take Ingrezza at any time of day. Just try to be consistent with how and when you take it.
Ingrezza Sprinkle capsules are a helpful option if you have trouble swallowing pills. You can swallow Ingrezza Sprinkle capsules whole, as well. Or, you can open them and sprinkle the contents onto 1 tbsp of soft food, such as applesauce, yogurt, or pudding. Try not to crush the granules, just mix them into the food gently with a spoon. Consume the mixture within 2 hours, followed by a full, 8 oz glass of water. Don’t sprinkle the contents into a liquid, such as milk or water.
What happens if you miss a dose of Ingrezza?
If you miss a dose of Ingrezza, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and take your next dose at the regular time. Don’t take 2 doses at the same time to make up for the one you missed.
If you miss several doses in a row, contact your prescriber. They can help you restart the medication safely.
What should you do if you take too much Ingrezza?
Taking an extra dose of Ingrezza by mistake may increase your risk of side effects, such as drowsiness, dry mouth, and constipation. In most cases, these effects are mild and go away on their own.
Taking a large amount of Ingrezza can be more serious. If you think you or a loved one has taken too much Ingrezza, contact your prescriber or call Poison Control at 1-800-222-1222. If any severe symptoms occur, seek emergency care right away.
How to save on Ingrezza
Ingrezza is only available as a brand-name medication. GoodRx can help you navigate ways to save on your prescription. Ingrezza is typically filled by a specialty pharmacy. The pharmacy staff can also help find ways to lower your Ingrezza cost, such as:
Save with a manufacturer copay card: If you have insurance coverage, you may pay as little as $0 per month for Ingrezza using a copay savings card from the manufacturer. A 30-day free trial is also available.
Save with a patient assistance program: If you’re uninsured or underinsured and meet certain income requirements, you may be able to access Ingrezza at no cost through the manufacturer’s patient assistance program.
The bottom line
Ingrezza (valbenazine) is a medication that treats movement disorders related to tardive dyskinesia and Huntington’s disease. The typical Ingrezza dosage is 80 mg once daily. In most cases, you’ll start taking 40 mg daily and work your way up to 80 mg daily over 1 to 2 weeks. Ingrezza comes in a capsule you can swallow whole as well as a sprinkle capsule you can open and mix into soft food.
You may need a lower Ingrezza dosage if you’re living with liver problems, have certain genetic differences, or take a medication that interacts with it. Your prescriber will help you find the right Ingrezza dosage for your needs.
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References
Ingrezza.com. (2025). Do your uncontrollable movements feel embarrassing? Neurocrine Biosciences.
Kane, M. (2025). Valbenazine therapy and CYP2D6 genotype. Medical Genetics Summaries: National Center for Biotechnology Information.
MedlinePlus. (2025). Valbenazine.
Neurocrine Biosciences. (2026). Ingrezza- valbenazine capsule [package insert].
Poison Control. (n.d.). Get Poison Control help online now. National Capital Poison Center.
Uhlyar, S. (2018). Valbenazine (Ingrezza): The first FDA-approved treatment for tardive dyskinesia. Pharmacy and Therapeutics.
