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Ilaris Coupon - Ilaris 1ml of 150mg/ml vial

Ilaris

canakinumab
Used for Rheumatoid Arthritis, Autoinflammatory Syndromes
Used for Rheumatoid Arthritis, Autoinflammatory Syndromes

Ilaris (canakinumab) is a type of monoclonal antibody known as an interleukin-1β (IL-1β) blocker. It's taken by adults and children to certain inflammatory conditions, including periodic fever syndromes, Still's disease (a rare type of arthritis), and gout flares. Ilaris (canakinumab) is injected under the skin every 1 to 2 months, depending on your condition, by a healthcare provider. Some of the more common side effects of Ilaris (canakinumab) include higher risk of infection and injection-site reactions.

Last reviewed on November 2, 2023
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What is Ilaris (canakinumab)?

What is Ilaris (canakinumab) used for?

How Ilaris (canakinumab) works

Ilaris (canakinumab) is a monoclonal antibody. More specifically, it's an interleukin antagonist. It blocks a protein from your immune system, called interleukin-1β (or interleukin-1 beta), to help lower inflammation in the body.

Drug Facts

Common BrandsIlaris
Drug ClassMonoclonal antibody
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Ilaris (canakinumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Please note: Side effects listed were reported by people who took Ilaris (canakinumab) for certain types of periodic fever syndromes (TRAPS, HIDS/MKD, and FMF).

Other Side Effects

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infections: fever, difficulty breathing, cough, weakness, sweating, chills, diarrhea, stomach pain, burning when you urinate, urinating more frequently
  • Serious allergic reactions: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Body aches or pain

chills

cough

diarrhea

dryness or soreness of the throat

fever

headache

hoarseness

joint pain

loss of appetite

muscle aches and pains

nausea

shivering

sneezing

stomach pain

stuffy or runny nose

sweating

tender, swollen glands in the neck

tightness in the chest

trouble breathing or swallowing

trouble sleeping

unusual tiredness or weakness

voice changes

vomiting

Incidence not known

Chest pain

lightheadedness or dizziness

skin rash, itching

swelling of the face, tongue, and throat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

feeling of constant movement of self or surroundings

increased weight

muscle or bone pain

sensation of spinning

weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Ilaris (canakinumab)

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Pros

Can be used in children and adults

Given once every month for most conditions

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Cons

Only available as an injection

Must be given by a healthcare provider

Unknown if safe to use during pregnancy

pharmacist-tips

Pharmacist tips for Ilaris (canakinumab)

pharmacist
  • Make sure to mark your appointments on your calendar to see your provider and receive your Ilaris (canakinumab) dose. This will help make sure you're properly being monitored and won't miss any doses.

    • Before you get any vaccines, tell your provider or pharmacist that you're taking Ilaris (canakinumab). Your providers can make sure the vaccines are safe for you to get. It's not known whether the medication affects how your body responds to vaccines.

      • Ilaris (canakinumab) can raise your risk of getting a serious or life-threatening infection. Avoid getting sick by washing your hands regularly and keeping away from people who are sick. Get medical help right away if you develop symptoms of an infection (e.g., fever, cough, difficulty breathing, diarrhea, weakness, sweating, chills) while you're taking Ilaris (canakinumab). You might have to stop taking Ilaris (canakinumab) so your body can fight and fully recover from the infection.

        • After Ilaris (canakinumab) is injected into your skin, it's normal to have some redness, itching, swelling, and bleeding at the injection site. If these reactions don't go away, tell your provider so they can check them out.

          • Make sure to tell your provider about all of the medications you're taking before and during treatment with Ilaris (canakinumab). Taking other medications that weaken your immune system with Ilaris (canakinumab) can raise your risk of serious infections.

            faqs

            Frequently asked questions about Ilaris (canakinumab)

            Who makes Ilaris (canakinumab)?
            Ilaris (canakinumab) is made by Novartis, a pharmaceutical company.
            Can Ilaris (canakinumab) be self-administered?
            No, you typically receive Ilaris (canakinumab) injections at your provider's office. But if appropriate, you might be able to arrange for a home health nurse to come to your house and give you the Ilaris (canakinumab) dose at home.
            Is Ilaris (canakinumab) an immunosuppressant?
            Yes, Ilaris (canakinumab) can be considered an immunosuppressant (a medication that weakens your immune system). This medication blocks a certain protein in your immune system. As a result, it makes the immune system less active.
            How quickly does Ilaris (canakinumab) work?
            How long it takes for Ilaris (canakinumab) to work will depend on what condition you're taking it to treat. For example, studies suggest that some people who take Ilaris (canakinumab) for CAPS might expect improvements in their symptoms (e.g., rash, joint pain, headaches) in as early as 1 week. And people who take Ilaris (canakinumab) for SJIA might experience their fever going away after 3 days and improvements in joint pain after about 2 weeks. Keep in mind that everyone responds to Ilaris (canakinumab) differently. So make sure to follow up with your provider about how well Ilaris (canakinumab) is working for your medical condition.
            Does Ilaris (canakinumab) cause weight gain?
            Yes, Ilaris (canakinumab) can cause gain weight. In clinical studies of people taking Ilaris (canakinumab) for CAPS, 11% of people gained weight while receiving treatment. To lower your risk for weight gain while taking Ilaris (canakinumab), make sure to have a healthy diet and regular exercise routine. Talk to your provider if you have more questions about Ilaris (canakinumab) and weight gain.
            Is Ilaris (canakinumab) safe to use during pregnancy?
            There isn't enough information to know if Ilaris (canakinumab) is safe to use during pregnancy. Like similar medications, it can pass from mother to baby, especially during the third trimester. As a result, babies born to mothers who took Ilaris (canakinumab) during pregnancy might have weaker immune systems. To lower the risk of getting sick, babies exposed to Ilaris (canakinumab) during pregnancy should avoid live vaccines for at least 4 to 12 months after the mother's last dose. If you're pregnant or thinking of becoming pregnant, speak to your healthcare provider about the risks and benefits of taking Ilaris (canakinumab).
            Can I get vaccinations while taking Ilaris (canakinumab)?
            Ask your provider before you receive any vaccines while taking Ilaris (canakinumab). There's limited research about how Ilaris (canakinumab) might affect the way vaccines work. Data shows that this medication isn't likely to affect inactive vaccines. But because Ilaris (canakinumab) weakens your immune system, there's a risk that you can get sick from live vaccines. Examples of live vaccines include the FluMist Quadrivalent (live-attenuated influenza vaccine) nasal spray and MMR (measles, mumps, and rubella vaccine). Check with your provider to make sure you're up-to-date with all vaccines before starting Ilaris (canakinumab).
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            warings-icon

            What are the risks and warnings for Ilaris (canakinumab)?

            Ilaris (canakinumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Risk of serious infections

            • Risk factors: Active, chronic (long-term), or recurrent infection | Other conditions that raise your risk of infection | Taking medications that weaken your immune system

              Ilaris (canakinumab) can make it more difficult for your body to fight off infections. This raises your risk of serious bacterial, viral, or fungal infections. The risk is higher for people who are taking or have recently taken other medications that weaken the immune system.

              Additionally, Ilaris (canakinumab) might reactivate (wake up) certain viruses that are already in your body, such as tuberculosis (TB) or hepatitis B. Before you start Ilaris (canakinumab) will check to see if you have any current infections.

              If you develop an infection, your provider will likely ask you to stop taking Ilaris (canakinumab) until your body fights off the infection. Let your provider know if you experience symptoms of these infections, such as fever, cough, difficulty breathing, or weakness.

              risk-warning

              Vaccinations

              Make sure you're up-to-date on routine vaccinations before you start Ilaris (canakinumab). It's unclear how Ilaris (canakinumab) might affect vaccines. But because Ilaris (canakinumab) interferes with your immune system, there's a chance vaccines won't work as well for you. In addition, you're recommended to avoid live vaccines while receiving Ilaris (canakinumab) because there's a risk that you can get sick from the live vaccines. Talk with your provider to see if you still need to schedule any vaccines.

              risk-warning

              Risk of macrophage activation syndrome (MAS)

              Taking Ilaris (canakinumab) might raise your risk of macrophage activation syndrome (MAS), a serious and life-threatening condition. Let your provider know if you experience symptoms of MAS, such as fever or bleeding that's difficult to stop.

              risk-warning

              Allergic reactions

              Allergic reactions to Ilaris (canakinumab) are possible. Most common reactions reported were rash at the injection site, a general rash, and hives. But allergic reactions can also include life-threatening reactions like facial swelling, shock, and anaphylaxis (closing of the throat). Get medical attention right away if you notice rash, hives, dizziness, a choking sensation, difficulty breathing, swelling around your eyes, or swelling of the lips or tongue after using Ilaris (canakinumab).

              dosage

              Ilaris (canakinumab) dosage forms

              Typical dosing for Ilaris (canakinumab)

              • Cryopyrin-associated periodic syndromes (CAPS):

                • Weight greater than 88 lbs (40 kg): The typical dose is 150 mg injected under the skin every 2 months.

                • Weight 33 lbs to 88 lbs (15 kg to 40 kg): The typical dose is 2 mg/kg of body weight injected under the skin every 2 months. In needed, your provider can raise the dose to 3 mg/kg every month (for children).

              • Other types of periodic fever syndromes (TRAPS, HIDS/MKD, and FMF):

                • Weight greater than 88 lbs (40 kg): The typical dose is 150 mg injected under the skin every month. If needed, your provider can raise the dose to 300 mg every month.

                • Weight of 88 lbs (40 kg) or less: The typical dose is 2 mg/kg of body weight injected under the skin every month. If needed, your provider can raise the dose to 4 mg/kg every month.

              • AOSD and SJIA:

                • Weight of 16.5 lbs (7.5 kg) or more: The typical dose is 4 mg/kg of body weight (maximum 300 mg) injected under the skin every month.

              • Gout flares:

                • Adults: The typical dose is 150 mg injected under the skin as a single dose. If needed, your provider might prescribe another dose at least 3 months after the previous dose.

              interactions

              Interactions between Ilaris (canakinumab) and other drugs

              Ilaris (canakinumab) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Ilaris (canakinumab). Please note that only the generic name of each medication is listed below.

              Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

              Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

              • Tofacitinib
              alternatives

              What are alternatives to Ilaris (canakinumab)?

              There are a number of medications that your doctor can prescribe in place of Ilaris (canakinumab). Compare a few possible alternatives below.
              Ilaris (canakinumab)
              Used for:
              Used for:
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              References

              Best studies we found

              Amarilyo, G. (2023). Overview of hereditary periodic fever syndromes. Merck Manual Professional Version.

              Arthritis Foundation. (n.d.). Systemic juvenile idiopathic arthritis.

              Bhargava, J., et al. (2022). Still disease. StatPearls.

              View All References (8)

              Bracaglia, C., et al. (2017). Macrophage activation syndrome: Different mechanisms leading to a one clinical syndrome. Pediatric Rheumatology Online Journal.

              Dhimolea, E. (2010). Canakinumab. mAbs.

              Dinarello, C. A., et al. (2013). Treating inflammation by blocking interleukin-1 in humans. Seminars in Immunology.

              Lachmann, H. J., et al. (2009). Use of canakinumab in the cryopyrin-associated periodic syndrome. The New England Journal of Medicine.

              National Organization for Rare Disorders. (2021). Adult-onset Still’s disease.

              Novartis Pharmaceuticals Corporation. (2023). Ilaris- canakinumab injection, solution [package insert]. DailyMed.

              Novartis Pharmaceuticals Corporation. (2023). Ilaris savings & support.

              Ruperto, N., et al. (2012). Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis. The New England Journal of Medicine.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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