Ibuprofen/Diphenhydramine is part of the NSAIDs class and treats Pain. NSAIDs (nonsteroidal anti-inflammatory drugs) are used to treat a wide variety of health conditions, such as acute pain, osteoarthritis, rheumatoid arthritis, and other types of pain and inflammation. They work by blocking certain enzymes in the body. Ibuprofen/Diphenhydramine is only available as a generic drug.