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Hymovis

high molecular weight viscoelastic hyaluronan
Used for Osteoarthritis

Hymovis is an injectable viscosupplement (or viscoelastic) that's given to relieve pain from osteoarthritis in the knee in adults. It's typically given when other pain-relieving therapies haven't worked well enough. Hymovis is given as two injections into your knee; each injection is separated by a week. Side effects aren't common but can include joint pain and stiffness.

Reviewed by:Last reviewed on July 18, 2024
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What is Hymovis?

What is Hymovis used for?

How Hymovis works

Hymovis is a viscosupplement, also known as a viscoelastic. It's a type of hyaluronic acid (or hyaluronan), which is a natural substance that's found in the connective tissues in your body. When Hymovis is injected into the knee, it provides structural support and it lubricates your knee joint. This helps lower pain from osteoarthritis.

Drug facts

Common BrandsHymovis
Drug ClassViscoelastic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Side effects of Hymovis

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Muscle, bone, and connective tissue problems (5%)
  • Joint pain (4%)

Less Common Side Effects

  • Joint swelling
  • Joint stiffness
  • Pain at the injection site
  • Redness at the injection site
  • Itchiness

Hymovis serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: rash; trouble breathing; swelling of lips, tongue, or throat

Source: Prescribing information

The following Hymovis side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Headache
  • Pain, redness, or irritation at injection site
  • Swelling in the joint where injected
  • Nausea
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Pros and cons of Hymovis

Pros

Cons

  • Must be given by a healthcare professional as an injection directly into the knee
  • Not a first-choice treatment option for knee pain from osteoarthritis
  • No lower-cost generic available; brand-name medication only
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Pharmacist tips for Hymovis

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  • Mark your appointments on your calendar to get your Hymovis injections. It's important not to miss your injections to help the medication work as best as possible for you.
  • It's possible to have pain and swelling in your knee(s) after you get your Hymovis injection. Avoid activities that put extra stress on your knee(s), like tennis, jogging, or jumping, for at least 2 days after your Hymovis injection. Also avoid doing any physical activity for a long period of time (for example, more than 1 hour) for at least 2 days after your injection.
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Risks and warnings for Hymovis

Hymovis can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Severe allergic reaction

  • Risk factors: Allergy to hyaluronic acid products | Allergy to Gram-positive bacterial proteins

Although rare, it's possible to have a serious allergic reaction to Hymovis. These allergic reactions can include difficulty breathing; hives; swelling of your face, lips, tongue, or throat; or any other symptom of anaphylaxis. Get medical help right away if you have an allergic reaction to Hymovis at any time during treatment.

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Hymovis dosage

Typical dosage for Hymovis

The typical dose is two injections into the affected knee. Each injection is separated by 1 week. Your healthcare professional will decide whether you need additional injections.

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Hymovis contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Hymovis will not be safe for you to take.

  • Current infection or skin problem in the injection area injection or knee joint
  • Known allergy to hyaluronic acid products
  • Known allergy to Gram-positive bacterial proteins
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News about Hymovis

References

Best studies we found

Ayhan, E., et al. (2014). Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World Journal of Orthopedics.

Bush, L. M. (2023). Overview of Gram-positive bacteria. Merck Manual Consumer Version.

Fidia Pharma USA Inc. (2021). Hymovis® High Molecular Weight Viscoelastic Hyaluronan.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.