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Glipizide/Metformin

Glipizide/Metformin Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on July 16, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (18%)
  • Headache (13%)
  • Cold or flu infection (10%)
  • Low blood sugar levels (9%)
  • Muscle pain (8%)
  • Nausea, vomiting (8%)
  • Stomach pain (6%)
  • Dizziness (5%)

Less Common Side Effects

  • Urinary tract infection
  • Liver problems

Glipizide/Metformin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Lactic acidosis: muscle pain, severe stomach pain, shallow breathing, tiredness or weakness, change in heartbeat
  • Dangerously low blood sugar levels: feeling hungry, fast heartbeat, shakiness, anxiety, sweating, tingling, dizziness, weakness, drowsiness, confusion, coma
When do Glipizide/Metformin possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Diarrhea
Nausea or vomiting
Stomach pain
Risk of dangerously low blood sugar levels
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Glipizide/Metformin side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Anxiety

blurred vision

chills

cold sweats

coma

confusion

cool pale skin

cough

depression

dizziness

fast heartbeat

fever

headache

increased hunger

nausea

nervousness

nightmares

seizures

shakiness

slurred speech

sneezing

sore throat

unusual tiredness or weakness

Less common

Bladder pain

bloody or cloudy urine

difficult, burning, or painful urination

frequent urge to urinate

lower back or side pain

pounding in the ears

slow heartbeat

Rare

Abdominal discomfort

decreased appetite

diarrhea

fainting spells

fast, shallow breathing

general feeling of discomfort

muscle pain or cramping

shortness of breath

sleepiness

Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur:

Abdominal discomfort

anxiety

behavior change, similar to drunkenness

blurred vision

cold sweats

coma

confusion

cool, pale skin

decreased appetite

diarrhea

difficulty in concentrating

drowsiness

excessive hunger

fast heartbeat

fast, shallow breathing

general feeling of discomfort

headache

muscle pain or cramping

nausea

nervousness

nightmares

restless sleep

seizures

shakiness

slurred speech

unusual sleepiness

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

Muscle or bone pain

stomach pain

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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