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Estratest

Estratest Side Effects

Cydnee Ng, PharmDKristianne Hannemann, PharmD
Reviewed by Cydnee Ng, PharmD, Kristianne Hannemann, PharmD
Last reviewed on April 10, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Change in menstrual bleeding patterns, including spotting
  • Breast tenderness
  • Breast enlargement
  • Deepening of the voice
  • Voice hoarseness
  • Acne
  • Nausea
  • Stomach cramps
  • Bloating
  • Headache or migraine
  • Dizziness

Less Common Side Effects

  • Vomiting
  • Hair loss
  • Excessive hair growth (e.g., more hair on the face)
  • Depression
  • Anxiety
  • Swelling in the feet or ankles
  • Changes in weight
  • Changes in sex drive
  • Patches of darkened skin on the face

Estratest serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Blood clots: trouble breathing, leg pain or swelling, skin that's warm to the touch
  • Heart attack: chest pain, arm pain, shortness of breath, cold sweat, lightheadedness
  • Stroke: sudden weakness on one side of your body, drooping face, changes in your speech or vision, confusion, headache
  • Breast lumps or pain: breast pain or soreness, swelling, rash
  • High calcium levels: tiredness, muscle weakness, nausea, vomiting, constipation, frequent urination, thirst, blood in the urine
  • Unusual vaginal bleeding

Source: DailyMed

The following Estratest side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Absent, missed, or irregular menstrual periods

acne or oily skin

decreased breast size

enlarging clitoris

hoarseness or deepening of the voice

menstrual changes

stopping of menstrual bleeding

unnatural hair growth or loss

Rare

Continuing nausea

cough

dark-colored urine

difficulty with swallowing

dizziness

fast heartbeat

fever

hives

itching

light-colored stools

loss of appetite

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

purple or red-colored spots on the body or inside the mouth or nose

shortness of breath

skin rash

sore throat

tightness in the chest

unusual tiredness or weakness

vomiting

wheezing

Incidence not known

Abdominal or stomach bloating, cramps, or pain

anxiety

bleeding from gums or nose

blistering, peeling, or loosening of the skin

bloating

bloody or cloudy urine

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

change in vaginal discharge

changes in skin color, pain, or tenderness

chest pain or discomfort

chills

clay-colored stools

clear or bloody discharge from nipple

confusion

constipation

convulsions

darkening of urine

decrease in amount of urine

diarrhea

difficult, burning, or painful urination

difficulty with breathing

difficulty with moving

difficulty with speaking

dimpling of the breast skin

dizziness or lightheadedness

double vision

eye pain

fainting

fever

fluid-filled skin blisters

frequent urge to urinate

headache

heavy bleeding

inability to move the arms, legs, or facial muscles

inability to speak

indigestion

inverted nipple

irregular heartbeats

itching of the vagina or genital area

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

loss of appetite

lump in the breast or under the arm

mood or mental changes

muscle cramps in the hands, arms, feet, legs, or face

muscle pain or stiffness

nausea

noisy, rattling breathing

numbness and tingling around the mouth, fingertips, or feet

pain

pain during sexual intercourse

pain in the ankles or knees

pain or discomfort in the arms, jaw, back, or neck

pain or feeling of pressure in pelvis

painful, red lumps under the skin, mostly on the legs

pains in the stomach, side, or abdomen, possibly radiating to the back

pelvic pain

persistent crusting or scaling of the nipple

pinpoint red or purple spots on the skin

poor insight and judgment problems with memory or speech

red, irritated eyes

redness or swelling of the breast

ringing in the ears

sensitivity to the sun

shortness of breath

skin thinness

slow speech

sore on the skin of the breast that does not heal

sore throat

sores, ulcers, or white spots in the mouth or on the lips

stomach pain

sudden shortness of breath or troubled breathing

sweating

swelling

swelling of the fingers, hands, feet, or lower legs

tenderness of the breast

thick, white curd-like vaginal discharge without odor or with mild odor

tiredness

tremor

trouble recognizing objects

trouble thinking and planning

trouble walking

troubled breathing at rest

unexpected or excess milk flow from breasts

unpleasant breath odor

vaginal bleeding

vision changes

vomiting of blood

weakness

weight gain

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Blemishes on the skin

brown, blotchy spots on the exposed skin

decreased interest in sexual intercourse

depression

headache, severe and throbbing

inability to have or keep an erection

increase or decrease in weight

increased hair growth, especially on the face

increased in sexual ability, desire, drive, or performance

increased interest in sexual intercourse

irritability

leg cramps

loss in sexual ability, desire, drive, or performance

loss of hair

mental depression

pimples

redness of the skin

swelling or inflammation of the mouth

twitching, uncontrolled movements of the tongue, lips, face, arms, or legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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