The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Skin rash (7%)
- Pain where the medication was applied (3%)
Less Common Side Effects
- Inflamed hair follicles (folliculitis)
- Skin thinning
- Repeated skin picking
- Peeling skin
Source: DailyMed
The following Duobrii side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Burning, itching, crusting, or peeling of treated skin
- Fragile or thinning skin that bruises easily
- Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
- Skin infection—skin redness, swelling, warmth, or pain
- Skin reactions on sun-exposed areas
- Small, red, pus-filled bumps on skin around hair follicles
- Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision lossSide effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
- Mild skin irritation, redness, or dryness
- Unexpected hair growth at application site

