The GoodRx Top 10 (January 2017)

Several times a year, GoodRx creates a list of the most expensive prescriptions in the U.S. To form our list, we use actual prices from a sample of claims as reported by pharmacies across the country. Prices are based on a 30-day supply of the most commonly prescribed form, dosage and quantity.

Rank Drug GoodRx Fair Price
1
Orange Diamond Gsi And 7985 - Harvoni 90mg-400mg Tablet
Harvoni (ledipasvir and sofosbuvir)
87,800 See Prices
Harvoni (ledipasvir and sofosbuvir) is another effective and well tolerated interferon-free option used for chronic genotype 1 hepatitis C infection. Harvoni results in sustained virologic response (SVR) rates, and thus effective cure, in over 90 percent of people with genotype 1 hepatitis C. How long you take Harvoni and whether you take it with ribavirin depend on your treatment history and whether or not you have liver cirrhosis. Cost and insurance coverage are an issue with Harvoni but its favorable side effect profile, minimal drug interactions, and its ease of administration (a single pill once daily) make it an attractive choice.
2
Yellow Oblong Gsi And 7977 - Sovaldi 400mg Tablet
Sovaldi (sofosbuvir)
73,800 See Prices
Sovaldi (sofosbuvir) is a hepatitis C virus polymerase inhibitor, available as a once-daily tablet. For patients with chronic genotype 1 hepatitis C infection, initiating therapy with simeprevir (Olysio) plus sofosbuvir (Sovaldi) for 12 weeks is the preferred regimen resulting in cure rates greater than 90 percent. Sovaldi is expensive in the United States, partly because the combination regimen of simeprevir plus sofosbuvir is not specifically approved by the Food and Drug Administration, so insurers may be reluctant to pay for it.
3
Pink Diamond Gsi And 7916 - Epclusa 400mg-100mg Tablet
Epclusa (velpatasvir and sofosbuvir)
73,300 See Prices
Used for the treatment of Hepatitis C virus infection, Epclusa is a combination of two medications: sofosbuvir 400 mg and velpatasvir 100 mg, which keep the virus from replicating, resulting in cure rates close to 99%. Epclusa is now one of the preferred treatments for patients with any type of chronic hepatitis C due to its effectiveness, once daily dosing, limited drug interactions, and relatively few side effects. Approved in July 2016, it is taken as a pill once daily for 12 weeks, and may be prescribed alone (for patients without cirrhosis) or with ribavirin (for patients with cirrhosis).
4
Zepatier (elbasvir and grazoprevir)
52,600 See Prices
Zepatier (elbasvir and grazoprevir) is used for the treatment of Hepatitis C. Zepatier is a combination tablet of two drugs that work by keeping the virus from replicating: elbasvir 50 mg and grazoprevir 100 mg. It is taken once daily for 12 weeks for the treatment of certain types of hepatitis C (genotype 1 or 4), with a cure rate of 99% for genotype 1 and 96% for genotype 4. Zepatier stands out because it can be used in patients with kidney impairment (renal insufficiency), unlike some other treatments. There is a limitation on its use though—11% of people with a certain type of hepatitis C are resistant to the medication, and the cure rate for those people is lower (91%).
5
White Oval 125Slxp - Fulyzaq 125mg Delayed-Release Tablet
Mytesi (icatibant, Firazyr)
Drug Class: Antidiarrheals
51,700 See Prices
Mytesi (icatibant) is used for hereditary angioedema (HAE) in people over 18 years of age. In 2016, the name was changed from Firazyr to Mytarsi. HAE is a rare disorder that leads to acute episodes of swelling in the throat often with airway compromise. Infusions under the skin at 30 mg per dose are given to patients with compromised breathing. Firazyr works by inhibiting bradykinin from binding to the receptor and treats the symptoms associated with acute attacks. It is one of the first line treatments of HAE attacks in adults.
6
White Targretin - Bexarotene 75mg Capsule
bexarotene (Targretin)
Drug Class: Retinoids
49,800 See Prices
Bexarotene (generic Targretin) is used for cutaneous (skin) T-cell lymphoma. Bexarotene is a retinoic acid gel or pill that is FDA approved for the treatment of skin lesions in patients with stages IA and IB cutaneous T cell lymphoma who have refractory or persistent disease after other therapies, or who have not tolerated other therapies.
7
Daklinza (daclatasvir)
Drug Class: NS5A Inhibitors
49,400 See Prices
Daklinza (Daclatasvir) is a newer hepatitis C medication that works by binding to a protein in the hepatitis C virus, which helps keep the virus from replicating. Daklinza specifically treats genotype 3 hepatitis C infections, which have historically been the most difficult to cure. Daklinza plus Sovaldi for 12 weeks is now the preferred regimen for patients with genotype 3. These two medications together result in a cure in 98 percent of patients.
8
Pink Oval 2V125 - ORKAMBI 200mg-125mg Tablet
Orkambi (lumacaftor and ivacaftor)
Drug Class: CFTR Potentiators
41,200 See Prices
Orkambi is a drug used to treat cystic fibrosis (CF). Orkambi is a combination of two medications (lumacaftor and ivacaftor), and is used only in CF patients with a specific genetic mutation (F508del). When used in CF patients with this mutation, Orkambi yields modest improvements in lung function and reduces episodes of deteriorating lung function. In studies, patients taking Orkambi had significant improvements in measured lung function, and improvement in weight and quality of life. The main side effects reported are chest discomfort and shortness of breath, particularly in patients with worse baseline lung function, so monitoring is recommended when Orkambi is first prescribed.
9
Beige Oval Av2 - Viekira Pak
Viekira Pak (ombitasvir, paritaprevir, ritonavir, and dasabuvir)
34,600 See Prices
Viekira Pak (ombitasvir/paritaprevir/ritonavir and dasabuvir) combines three hepatitis C virus antiviral agents with different mechanisms of action into one pill. Viekira Pak is ombitasvir/paritaprevir/ritonavir in one pill and dasabuvir in another pill. This newer interferon-free regimen is used with or without ribavirin in patients with genotype 1a or 1b infection. Viekira Pak comes in a convenient punch out kit where you take 2 tablets of the mixture of ombitasvir/paritaprevir/ritonavir and 1 tablet of dasabuvir twice a day for 12 or 24 weeks depending on your genotype. It is highly effective in treatment-naïve hepatitis C patients and in those who have failed prior treatment with peginterferon and ribavirin, even in the setting of cirrhosis. Viekira Pak results in a sustained viral response (cure) in greater than 95% of patients with hep C.
10
yellow - H.P. Acthar Gel 80unit/ml Repository Injection
HP Acthar (corticotropin)
40,800 See Prices
HP Acthar (corticotropin) is an injection that stimulates the adrenal cortex to secrete adrenal steroids (including cortisol) and aldosterone, working as a potent anti-inflammatory. It is used for acute exacerbations of multiple sclerosis (MS) and gout, among other conditions. HP Acthar is a purified form of bovine (cow) or porcine (pig) adrenocorticotropic hormone (ACTH) and is an expensive alternative to glucocorticoids like Solu-medrol. It can be used in patients with MS who cannot tolerate high-dose glucocorticoids or prefer self-injection (instead of intravenous infusion).

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GoodRx is not sponsored by or affiliated with any of the pharmacies identified in its price comparisons. All trademarks, brands, logos and copyright images are property of their respective owners and rights holders and are used solely to represent the products of these rights holders. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. GoodRx provides no warranty for any of the pricing data or other information. Please seek medical advice before starting, changing or terminating any medical treatment.