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Cuvrior Coupon - Cuvrior 300mg tablet

Cuvrior

Used for Wilson's Disease
Used for Wilson's Disease

Cuvrior (trientine tetrahydrochloride) is a newly approved medication that's used to treat a rare genetic condition called Wilson's disease in adults. It can only be used in people with stable Wilson's disease who are able to take penicillamine (Depen).

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on June 2, 2022
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageAlternativesLatest newsImagesPricesMedicare
basics-icon

What is Cuvrior (trientine tetrahydrochloride)?

What is Cuvrior (trientine tetrahydrochloride) used for?

  • Wilson's disease in people with copper levels that are under control and who can take penicillamine (Depen)

How Cuvrior (trientine tetrahydrochloride) works

Cuvrior (trientine tetrahydrochloride) is a chelating agent. People with Wilson's disease have high amounts of copper which can cause organ damage. Cuvrior (trientine tetrahydrochloride) works by attaching to copper in your body, preventing it from getting absorbed from your gut, and allows your body to remove it through your urine. This helps to keep your copper levels low.

Are you looking for information on trientine (Syprine) instead?

Drug Facts

Common BrandsCuvrior
Drug ClassChelating agent
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Cuvrior (trientine tetrahydrochloride)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pain (19%)
  • Change of bowel habits (15%)
  • Rash (12%)
  • Hair loss (8%)
  • Mood swings (8%)

Other Side Effects

  • Anemia (low red blood cell count)
  • Lupus
  • Muscle damage
  • Muscle spasm

Source: FDA

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
  • Lupus-like syndrome—joint pain, swelling, or stiffness, butterfly-shaped rash on the face, rashes that get worse in the sun, fever, unusual weakness or fatigue

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Cuvrior (trientine tetrahydrochloride)

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Pros

Works just as well as penicillamine (Depen) to lower copper levels in people with Wilson's disease

Scored tablets can be broken in half for people who have difficulty swallowing whole pills

Can be stored at room temperature

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Cons

Must be taken on an empty stomach

Can't be used in people who aren't able to take penicillamine (Depen)

Has many interactions with foods, drinks, medications, and supplements

pharmacist-tips

Pharmacist tips for Cuvrior (trientine tetrahydrochloride)

pharmacist

  • Your dose of Cuvrior (trientine tetrahydrochloride) will depend on your previous dose of penicillamine (Depen). Stop taking penicillamine (Depen) before starting Cuvrior (trientine tetrahydrochloride).

    • Take Cuvrior (trientine tetrahydrochloride) on an empty stomach, at least 1 hour before or 2 hours after meals. You should also take it 1 hour away from any other food or milk. This is because it can attach to certain foods and drinks which might prevent the medication from getting absorbed and working properly.

      • Make sure to keep the Cuvrior (trientine tetrahydrochloride) tablet inside of the blister pack until you're ready to take it so moisture from the air doesn't damage the medication. Don't use a pill box to store the medication.

        • Don't crush, chew, or dissolve Cuvrior (trientine tetrahydrochloride) tablets since this can damage the medication and cause it to work less well.

          • If you have trouble swallowing whole pills, you can divide the tablet into two equal halves on the line in the middle of the tablet. Tell your provider if you have trouble swallowing tablets since this might not be the best option for you if you do.

            • Keep up with your scheduled lab work so your provider can monitor your copper levels properly and see if Cuvrior (trientine tetrahydrochloride) is working for you. They might need to adjust your dose based on your lab results.

              faqs

              Frequently asked questions about Cuvrior (trientine tetrahydrochloride)

              Can Cuvrior (trientine tetrahydrochloride) cure Wilson's disease?
              No. There isn't a cure for Wilson's disease, and people with this condition will need lifetime treatment to keep copper levels under control. There are medications like Cuvrior (trientine tetrahydrochloride) that can help remove too much copper in the body due to Wilson's disease, and prevent build up of copper that can lead to serious health problems. Speak with your provider about the best treatment option for you.
              Will Cuvrior (trientine tetrahydrochloride) interact with my other medications?
              Cuvrior (trientine tetrahydrochloride) can interact with many medications because of the way it works to treat Wilson's disease. It can attach to medications and supplements in your stomach and prevent them from getting absorbed into your body. This might cause certain medications and supplements to work less well for you. It's recommended to take Cuvrior (trientine tetrahydrochloride) 1 hour away from other medications you're taking by mouth. If you're taking iron, you should take Cuvrior (trientine tetrahydrochloride) at least 2 hours before or 2 hours after it. For other mineral supplements (e.g., zinc, calcium, magnesium), you should take Cuvrior (trientine tetrahydrochloride) at least 1 hour before or 2 hours after your supplement. If you have questions about this, speak with your provider or pharmacist.
              Can I take Cuvrior (trientine tetrahydrochloride) if I had bothersome side effects from penicillamine (Depen)?
              If you had to stop taking penicillamine (Depen) (a first-choice treatment option for Wilson's disease) because of bothersome or life-threatening side effects, you likely aren't able to take Cuvrior (trientine tetrahydrochloride). This is because Cuvrior (trientine tetrahydrochloride) was only studied to be safe and work well in people who previously took penicillamine (Depen) for at least 1 year. Discuss with your provider if Cuvrior (trientine tetrahydrochloride) is a good option for you.
              What's the difference between Syprine and Cuvrior?
              Both Syprine and Cuvrior contain the same active medication (trientine) that's used to treat Wilson's disease, but there are a few differences. For one, Syprine must be refrigerated, while Cuvrior is more conveniently stored at room temperature. Also, each medication is made slightly differently: Syprine contains trientine dihydrochloride whereas Cuvrior, a new formulation, contains trientine tetrahydrochloride. When compared to each other, Cuvrior (trientine tetrahydrochloride) is absorbed faster and in greater amounts. While Cuvrior can be used in people who don't have harmful side effects from penicillamine (Depen), Syprine can only be used in people who can't take penicillamine (Depen) because of bothersome or life-threatening side effects.
              Is Cuvrior (trientine tetrahydrochloride) safe to use during pregnancy?
              There isn't enough information available to know if Cuvrior (trientine tetrahydrochloride) is safe to take during pregnancy. But, another form of Cuvrior (trientine tetrahydrochloride) that's available as trientine hydrochloride (Syprine) has been used over several decades, and no risks for major birth defects, miscarriages, or harm to unborn babies or pregnant mothers have been found. It has, however, caused harm to unborn babies in animal studies. It's important to treat Wilson's disease during pregnancy to avoid worsening symptoms and the risk of miscarriage or other harmful effects to your baby. Discuss the risks and benefits of taking Cuvrior (trientine tetrahydrochloride) during pregnancy with your healthcare provider.
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              What are the risks and warnings for Cuvrior (trientine tetrahydrochloride)?

              Cuvrior (trientine tetrahydrochloride) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Worsening of symptoms

              When you first start taking Cuvrior (trientine tetrahydrochloride), the copper in your body moves around until your levels are stable. This can cause worsening of your symptoms, including brain problems. Let your provider know if you start to feel worse when beginning treatment with Cuvrior (trientine tetrahydrochloride) and they might adjust your dose or even stop the medication. Your provider will monitor your copper levels when you first start taking Cuvrior (trientine tetrahydrochloride), after 3 months, and then every 6 months.

              risk-warning

              Low copper and iron levels

              • Risk factors: Pregnancy | Menstruation | Low copper diet

                Cuvrior (trientine tetrahydrochloride) can sometimes cause copper and iron levels to get too low. Pregnant women are at a higher risk since the amount of copper they need is often greater. Women who are on their period are at a higher risk of having low iron levels. A low copper diet that's commonly recommended in people with Wilson's disease can also lead to low iron levels. Let your provider know if you experience symptoms of low copper or iron levels including muscle weakness, dizziness, feeling tired, confusion, or tingling in your feet or hands. Your provider might recommend that you take an iron supplement, but take it at least 2 hours away from Cuvrior (trientine tetrahydrochloride) to prevent any interaction.

                risk-warning

                Allergic reaction

                Rash was a commonly reported side effect of Cuvrior (trientine tetrahydrochloride) in the clinical studies. If you develop a rash or other allergic reaction during treatment with Cuvrior (trientine tetrahydrochloride), contact your provider to discuss whether you should continue taking it or switch to a different medication.

                dosage

                Cuvrior (trientine tetrahydrochloride) dosage forms

                Typical dosing for Cuvrior (trientine tetrahydrochloride)

                Your dose will depend on the dose of penicillamine (Depen) you were taking.

                The typical dose ranges from 300 mg to 3,000 mg by mouth on an empty stomach per day, split into two doses throughout the day.

                alternatives

                What are alternatives to Cuvrior (trientine tetrahydrochloride)?

                There are a number of medications that your doctor can prescribe in place of Cuvrior (trientine tetrahydrochloride). Compare a few possible alternatives below.
                Cuvrior (trientine tetrahydrochloride)
                Used for:

                • Wilson's disease in people with copper levels that are under control and who can take penicillamine (Depen)

                View Prices
                Penicillamine (Depen)
                Used for:

                • Wilson's disease

                • Cystinuria

                • Severe rheumatoid arthritis (RA) when other medications haven’t worked well

                $844.16 Lowest GoodRx priceView Prices
                Trientine (Syprine)
                Used for:

                • Wilson's disease in people who can't take penicillamine (Depen)

                $6848.00 Lowest GoodRx priceView Prices
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                This medicine is Yellow, Oblong Tablet Imprinted With "Ol75 Ol75".Yellow Oblong Ol75 Ol75 - Cuvrior 300mg Tablet
                Yellow Oblong Ol75 Ol75 - Cuvrior 300mg Tablet
                This medicine is Yellow, Oblong Tablet Imprinted With "Ol75 Ol75".Yellow Oblong Ol75 Ol75 - Cuvrior 300mg Tablet

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