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Cosela Medicare coverage

Used for Chemotherapy Side Effects

Cosela (trilaciclib) is a medication that's used to prevent low blood cell counts from certain anticancer medications. It's given to people with extensive-stage, small-cell lung cancer (ES-SCLC) before chemotherapy to help protect the bone marrow from getting damaged. You'll likely receive Cosela (trilaciclib) at an infusion center, and it's only available as a brand medication, so it might be expensive.

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Annual Notice of Change (ANOC):

The Medicare Annual Notice of Change (ANOC) is a letter for people enrolled in Medicare Advantage plans and anyone with Medicare Part D prescription coverage. People with Medicare Advantage or original Medicare (Part A and/or Part B) can have Part D plans. The ANOC informs enrollees about any changes to their benefits for the coming coverage year. By law, Medicare Advantage and Part D plans must send the ANOC to enrollees by September 30 — which is before the annual Medicare open enrollment period of October 15 to December 7. Even if you have the same plan, your benefits could change year to year.

Premium:

A premium is the cost of having a health insurance plan and is usually paid monthly. Medicare enrollees may pay several premiums. Most people don’t pay anything for Part A hospital insurance, but some people do depending on how long they worked and paid taxes. For outpatient and preventive coverage, the Part B standard premium is $185 a month in 2025, but people with higher incomes pay more. Your premium for Medicare Advantage plans will vary, but even so-called “zero premium” plans require you to pay your Part B premium. Part D premiums range in price, but the average is about $47 a month in 2025. If you have original Medicare and a Medigap supplement plan, you have an additional premium for that coverage.

Deductible:

A deductible is the amount you pay out of pocket before your Medicare plan begins cost-sharing. In 2025, the Part A deductible is $1,676 per benefit period. The Part B deductible is $257 for the year, but you can access certain preventive care — including some vaccines — without meeting your deductible. Medicare Advantage deductibles vary and your Part D deductible can’t exceed $590 in 2025.

Out-of-pocket limit:

Original Medicare has no annual out-of-pocket maximum. Medicare Advantage plans have out-of-pocket limits. In 2025, they are $9,350 for in-network covered services and $14,000 for in-network and out-of-network covered services combined.

Medicare Prescription Payment Plan:

Starting January 1, 2025, anyone with Part D coverage had the option to use the Medicare Prescription Payment Plan for their out-of-pocket medication costs instead of paying upfront at the pharmacy. This plan doesn’t provide savings, but allows you to spread prescription costs — including your deductible — over the year. Making payments can be particularly helpful for people who may skip or delay picking up prescriptions because of high costs early in the year. Also in 2025, the Part D out-of-pocket limit dropped to $2,000.

Initial coverage phase:

After a Medicare enrollee meets the Part D deductible (if the plan has one), the health insurance begins cost sharing. The initial coverage phase means you pay coinsurance or a copay for covered prescriptions.

Catastrophic phase:

When you reach the $2,000 out-of-pocket maximum, your Part D plan pays for 100% of covered medications for the rest of the year.

Medication ready
How to save on drugs with Medicare

Medicare Part D is the part of Medicare that helps cover prescription medications, including both brand name and generic. It also includes coverage for certain vaccines that aren’t covered by Part B, as well as some medical supplies.

Even with Medicare Part D coverage, you may still have out-of-pocket costs such as premiums, deductibles, copayments, and coinsurance. As of 2025, Medicare Part D plans include a $2,000 annual out-of-pocket cap. Once you reach this limit, your plan covers the full cost of your covered medications for the rest of the year.

Still, there are several ways to reduce your prescription medication cost. From GoodRx coupons to patient assistance programs, here are ways you can save money on the medications you need.

1. See if you qualify for Medicare’s Extra Help program

The Medicare Extra Help/Low-Income Subsidy program is a federally funded program for people covered under a Medicare Part D plan. It helps reduce enrollees’ out-of-pocket costs by limiting their deductibles and copays. To qualify, your income and assets fall below a certain limit.

If you’re eligible, you may receive:

  • No monthly premiums for Medicare Part D

  • No Medicare Part D deductible

  • Low copays for prescription medications

2. Use GoodRx coupons

You can’t combine GoodRx coupons with Medicare, but you can choose to use a coupon instead of your insurance if it results in a lower price.

Here’s how to download a GoodRx coupon:

  1. Go to the GoodRx website, or download the GoodRx app on your phone.

  2. Search for your prescription medication.

  3. Enter your prescribed dose and quantity, then set your location.

  4. Compare prices across different pharmacies in your area.

  5. Click “Find the lowest prices” or press “Enter.”

  6. You can have the coupon sent by text or email, or print it out.

  7. To apply the discount, show the coupon at the pharmacy when you fill your prescription. Ideally, this is done at drop-off before the prescription is filled.

3. Consider the Medicare Prescription Payment Plan

The Medicare Prescription Payment Plan is a new program that can help make paying for medications more manageable. It’s open to anyone with a standalone Part D plan or those with Medicare Advantage plans that offer prescription medication coverage.

There is no cost to participate in the Medicare Prescription Payment Plan and participation is voluntary. Instead of paying for the total cost of your medications up front at the pharmacy, the payment plan allows you to spread the cost into smaller payments during the year. If you join, you will continue to pay your premium every month as well as an additional monthly amount on your payment plan. It’s a good idea to review how the Medicare Prescription Payment Plan works to determine if it’s right for you.

4. Compare Part D plans during open enrollment

Medicare open enrollment, which takes place every year from October 15 to December 7, is your chance to switch plans if another option offers better prescription medication coverage or lower costs. Plan costs and coverage details can change each year, so it’s important to review your options.

Here are some steps to help you compare plans:

  1. Make a list of all your medications and what dosages you take.

  2. Enter the names of your prescription medications to see which plans offer the best coverage.

  3. Look at premiums, deductibles, and medication costs for each plan. Plans usually change their formularies, premiums, and copays annually.

  4. Check if your preferred pharmacy is in each plan's network.

5. Get a 90-day supply

Opting for a 90-day supply instead of a monthly refill of your medication might help reduce your long-term out-of-pocket costs. Many insurance plans offer lower copays or bulk pricing for 3-month prescriptions.

If your medication is covered under your plan, see if your insurer’s mail-order or specialty pharmacy provides savings on a 90-day supply. If they do, ask your prescriber to write a prescription for a 90-day quantity to take advantage of these potential savings.

6. Ask about the generic version of your medication

Some medications have a generic version, and they generally cost less than the brand-name prescriptions. Generic medications are just as safe and effective as brand-name medications, so it’s an option worth considering to reduce your cost. Ask your prescriber about switching to a generic version of your medication to save money.

7. Consider lower-cost alternative medications

There may be other medications that help manage your condition, and they may cost less. If your medication is costly or not covered by your insurance, talk to your prescriber about lower-cost alternatives that might be a good option for you. Alternatives might have better insurance coverage or lower costs.

8. Learn more about patient assistance programs

Patient assistance programs (PAPs) offer free or low-cost medications to uninsured and low-income consumers. These programs, which primarily offer savings on brand-name medications, are usually run by private pharmaceutical companies or nonprofit organizations. You must meet certain qualifications and complete paperwork to receive savings from PAPs. However, some PAPs exclude Medicare recipients, so it’s important to review the program’s rules and requirements carefully.

9. Check state-funded resources

Depending on where you live, your state may offer programs to help you navigate prescription medication costs. A good place to start is your local Department of Aging. This U.S. Department of Health and Human Services office can help you find the best Medicare plan for the coverage you need.

Some states even have their own cost-saving programs for older adults. For example, Pennsylvania runs PACE and PACENET. These programs help eligible residents get prescription medications at reduced costs.

Alternatively, you can find out if your state has a State Pharmaceutical Assistance Program by using Medicare’s search tool. These programs are state-run and help qualifying residents pay for prescription medications.

10. Use a health savings account to pay for prescription medications

Although you can’t contribute to a health savings account (HSA) after enrolling in Medicare, you can still use any remaining funds in your account to pay for qualified medical expenses. An HSA allows you to use tax-free dollars to pay for eligible prescription medications. The money in your account does not expire so you can use your funds at any time to reduce your out-of-pocket medication costs.

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Frequently asked questions about Cosela

Cosela is a medication used to protect the bone marrow from certain chemotherapy treatments. Your bone marrow contains the "parent cells" of your red blood cells, white blood cells, and platelets and is where your blood cells are made. Cosela is given before treatments containing platinum medications and etoposide (Toposar) together or treatment with topotecan (Hycamtin) alone. Cosela works by temporarily blocking certain proteins called kinases that specifically control cell growth in your body. When you receive an infusion of Cosela, it blocks these proteins from working, which stops the "parent cells" in your bone marrow from growing. Doing so can protect these "parent cells" from being damaged by anticancer medications. This lowers the risk of low blood cell counts and its complications like infections, anemia, and bleeding. After your chemotherapy dose, the effect of Cosela slowly wears off, and your bone marrow can start making blood cells again.

Cosela is typically injected into the veins by a healthcare provider on your chemotherapy treatment days. In general, it's a 30-minute infusion that's given within 4 hours before chemotherapy. Your Cosela dose depends on your body surface area (BSA), which is your body size calculated based on weight and height. Your provider will determine the dose you need before each infusion.

One of the more common side effects of Cosela is an injection site reaction. These reactions can happen anytime during your infusion and up to 15 days after your dose. Your provider will observe you for any signs of swollen veins or redness at the injection site during treatment to make sure this medication is safe for you. Tell your provider right away if you notice any swelling, pain, redness, tenderness, itchy skin, or skin that feels warm to the touch after receiving Cosela. Other common side effects include fatigue, headache, belly pain, and high blood sugar. Talk with your provider if you have any concerns about receiving Cosela.

Rarely, Cosela can cause allergic reactions or anaphylaxis, which can be life-threatening. In addition, rare cases of lung problems, such as pneumonitis (lung inflammation) or interstitial lung disease (ILD; scarring of the lungs), have occurred in people given kinase inhibitors like Cosela. Before receiving Cosela, let your provider know if you have a history of lung problems. During your infusion, your provider will watch for signs and symptoms of allergic reactions and breathing problems to make sure this medication is safe for you. Tell your provider right away if you experience signs and symptoms of an allergic reaction — like hives, itching, flushed or pale skin, trouble breathing, swollen face, dizziness, or fainting. Also contact your provider if you experience shortness of breath, cough, or tiredness, which can be symptoms of lung problems.

You should be careful about receiving Cosela if you have a history of liver problems. This medication can raise your liver protein levels, which your provider uses to check the health of your liver. Before starting Cosela, let your provider know if you've ever had liver problems before so they can decide whether this medication is safe for you.

You shouldn't receive Cosela if you're pregnant, planning to get pregnant, or breastfeeding. Cosela can cause harm to your unborn baby if you're pregnant. Before your first infusion, your provider might ask you to get a pregnancy test done to make sure this medication is safe for you. Once you start treatment with Cosela, make sure to use an effective form of birth control, such as birth control pills, during treatment and for 3 weeks after your last dose. This will help prevent pregnancy during treatment. Based on animal studies, it’s possible that Cosela might lower your ability to have children during treatment if you're female. Since animal studies don’t always represent what happens in humans, discuss with your provider about any family planning concerns you might have. It's also not clear whether Cosela is safe while breastfeeding. But since the medication carries a risk of serious side effects that might affect breastfed babies, it's recommended that you don't give your baby breast milk during Cosela treatment and for 3 weeks after your last dose. Ask your provider about other ways to feed your baby.