The average list price of Ayvakit (Avapritinib) is $38,929.00, but your out of pocket cost will likely be less if you have insurance. Ayvakit is covered by some Medicare and insurance plans. This drug is also a limited distribution drug, meaning it is not available at retail pharmacies. Refer to the Key Takeaways for additional information on Ayvakit and check our savings tips for other ways to reduce your cost. A generic version of Ayvakit is not yet available.