Key takeaways:
Januvia (sitaglipitin) is a medication used to treat Type 2 diabetes.
Januvia doesn’t interact with any foods. But there are still some foods and eating patterns you should avoid while taking Januvia.
Limit sugary drinks, refined carbohydrates, and alcohol while taking Januvia.
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Januvia (sitagliptin) is a medicine that can treat Type 2 diabetes. It works by raising levels of helpful hormones that make it easier for your body to keep blood sugar in a healthy range.
Unlike some medications, Januvia doesn’t interact with any foods or drinks. This means there isn’t anything you absolutely can’t eat or drink while taking Januvia.
But there are foods and drinks that can keep Januvia from working at its best. Here are five foods and drinks you should limit while taking Januvia so you can get the best results while taking this medication.
1. Refined carbohydrates
Refined carbohydrates lack fiber and nutrients found in whole grains. Examples of refined carbohydrates include:
While bread
White rice
White pasta
Baked goods like cookies and cakes
Crackers
Your body digests refined carbohydrates very quickly. This makes your blood sugar rise quickly. Januvia helps your body manage changes in blood sugar after you eat. But blood sugar spikes are more difficult to control than the slower increases that happen after you eat complex carbohydrates, like those in whole grains.
Limiting refined carbohydrates makes it easier for Januvia to keep your blood sugar in a healthy range after you eat and throughout the day.
2. Sugary drinks
It’s a good idea to avoid drinks that are high in sugar because they can raise your blood glucose. This makes it harder for Januvia to keep your blood sugar within a target range.
Examples of sugary drinks include:
Soda
Energy drinks
Sweetened iced tea
Fruit juice
Sports drinks
Coffee and diabetes: Here’s how caffeine can affect your insulin sensitivity and blood sugar levels.
Alcohol and blood sugar: Learn how alcohol can affect your blood sugar if you have diabetes.
Refined carbs and diabetes medications: Here’s how refined carbohydrates — like those in white breads and white rice — work against your diabetes medication.
Experts recommend limiting your added sugar intake to 25 g to 36 g each day, but most people eat 2 to 3 times more than that.
You don’t have to cut out sugar entirely to get the best results from Januvia. But it’s a good idea to stick to the recommended limits. You can check for added sugar in drinks by reading the nutrition labels on the packaging.
3. High-glycemic vegetables
A healthy diet should be rich in whole fruits and vegetables. But not all vegetables affect your blood sugar the same way. Some vegetables have a high glycemic index, which means they raise your blood sugar fast. These include starchy vegetables like:
Potatoes
Peas
Yams
Sweet potatoes
You want to avoid blood sugar spikes to help Januvia work as effectively as possible. This doesn’t mean you have to cut out starchy vegetables completely. But enjoy them in moderation and choose low-glycemic vegetables when possible.
4. Alcohol
There’s no amount of alcohol that’s safe for your health. And that’s especially true when you’re taking Januvia.
Januvia can trigger hypoglycemia (low blood sugar). This is rare. But if you have diabetes, alcohol increases your risk of hypoglycemia. You can lower your risk by not mixing Januvia and alcohol.
You don’t need to avoid alcohol completely, but you should limit your intake, eat food while drinking, and avoid sugary mixed drinks.
5. Garlic supplements
Garlic is a vegetable used to flavor many dishes. It has many potential health benefits and can help lower your blood sugar. This can be a good thing if you have diabetes. But too much garlic can also increase your risk of hypoglycemia.
You have to eat a lot of garlic to trigger hypoglycemia. And most people won’t eat that much in one sitting. So, it’s safe to keep eating your favorite garlicky foods.
But it’s easy to get too much garlic from concentrated products like garlic supplements. Avoid garlic supplements and other concentrated forms of garlic if you’re taking Januvia.
Frequently asked questions
Januvia may cause mild side effects, like diarrhea or an upset stomach. These symptoms can sometimes be confused with reactions to certain foods. People taking Januvia should avoid a strict ketogenic diet, because drastically reducing carbs can lead to dangerously low blood sugar.
Vitamin D doesn’t interact with Januvia. It’s safe to take both at the same time.
Januvia can be taken at any time of day, with or without food. Try to take your medication at the same time each day. This helps Januvia work best.
Januvia may cause mild side effects, like diarrhea or an upset stomach. These symptoms can sometimes be confused with reactions to certain foods. People taking Januvia should avoid a strict ketogenic diet, because drastically reducing carbs can lead to dangerously low blood sugar.
Vitamin D doesn’t interact with Januvia. It’s safe to take both at the same time.
Januvia can be taken at any time of day, with or without food. Try to take your medication at the same time each day. This helps Januvia work best.
The bottom line
Januvia is a medication that can help manage Type 2 diabetes. It doesn’t interact with any food or drinks. But certain foods and drinks can stop Januvia from working at its best. Try to limit foods that cause blood sugar spikes while taking Januvia. This includes refined carbohydrates, sugary drinks, and high-glycemic (starchy) vegetables. You should also limit alcohol and avoid garlic supplements, as these can increase your risk of hypoglycemia (low blood sugar) while taking Januvia.
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References
American Diabetes Association. (n.d.). Get to know carbs.
American Heart Association. (2024). How much sugar is too much?
Arkansas Heart Hospital. (n.d.). Glycemic index chart.
Nagao, M. et al. (2023). Efficacy and safety of sitagliptin treatment in older adults with moderately controlled type 2 diabetes: the STREAM study. Scientific Reports.
Shabani, E., et al. (2019). The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis. Primary Care Diabetes.
World Health Organization. (2023). No level of alcohol consumption is safe for our health.












