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Depression

Medications for Depression: How Long Does It Take to Find Relief?

You may have to be patient when starting an antidepressant for major depressive disorder.

Lauren Smith, MASanjai Sinha, MD
Written by Lauren Smith, MA | Reviewed by Sanjai Sinha, MD
Updated on July 3, 2025
Featuring Jacques Ambrose, MD, MPH, FAPAReviewed by Sanjai Sinha, MD | July 3, 2025

Some people struggle with symptoms of major depressive disorder for months or years before seeking treatment. As a result, they may be very eager to see results when starting medication for depression.

Some people may see improvements within a few days, but others may need to wait several weeks to know if the medication is working, according to Jacques Ambrose, MD, MPH, FAPA, Psychiatrist at Columbia University Irving Medical Center.

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Lauren Smith, MA
Written by:
Lauren Smith, MA
Lauren Smith, MA, has worked in health journalism since 2017. Before joining GoodRx, she was the senior health editor and writer for HealthiNation.
Sanjai Sinha, MD
Reviewed by:
Sanjai Sinha, MD
Sanjai Sinha, MD, is a board-certified physician with over 20 years of experience. He specializes in internal medicine.

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