Xbryk vs. Xgeva for Multiple Myeloma and Hypercalcemia: Important Differences and Potential Risks.

Xbryk

(denosumab)

Xgeva

(denosumab)

Summary for Xbryk

Prescription only

Xbryk (denosumab or denosumab-dssb) is a biosimilar to Xgeva (denosumab). It's a RANKL inhibitor that's FDA approved to prevent bone complications in people with certain types of cancer. The medication is also used to treat giant cell tumor of bone and high calcium levels caused by cancer. Xbryk (denosumab) is injected under the skin by a healthcare professional, usually once a month. Common side effects include nausea, tiredness, and diarrhea.

Indications for Xbryk

Prevention of bone problems in adults with multiple myeloma or certain cancers that have spread to the bones
Giant cell tumor of bone in adults and certain teens who can't have surgery
High calcium levels caused by cancer (hypercalcemia of malignancy) in adults after bisphosphonate treatment hasn't worked

Pros and Cons for Xbryk

Pros

Helps reduce serious bone problems caused by cancers
Can be used for many cancer-related bone conditions
Typically injected once a month

Cons

Must be injected by a healthcare professional
Requires regular blood tests
Not safe in pregnancy

Common Side Effects for Xbryk

Cancer that has spread to the bones:

Tiredness (45%)
Low phosphate levels (32%)
Nausea (31%)

Multiple myeloma:

Diarrhea (34%)
Nausea (32%)
Low red blood cells (22%)
Back pain (21%)

Giant cell tumor of bone: (all ≥ 10%)

Joint pain
Back pain
Pain in the arms and legs
Tiredness
Headache
Nausea
Common cold symptoms
Muscle or bone pain
Toothache
Vomiting
Low phosphate levels
Constipation
Diarrhea
Cough

High calcium due to cancer:

Nausea (30%)
Shortness of breath (27%)
Reduced appetite (24%)
Headache (24%)
Swelling (24%)
Vomiting (24%)
Low red blood cell count (21%)
Constipation (21%)
Diarrhea (21%)

Warnings for Xbryk

Serious allergic reactions
Low calcium levels
Jaw bone problems (osteonecrosis of the jaw)
Thigh bone fractures
High calcium levels after stopping treatment
Spinal fractures after stopping treatment
Harm to unborn baby

Summary for Xgeva

Prescription only

Xgeva (denosumab) is a RANKL inhibitor used to help prevent serious bone problems caused by cancer. It's also approved to treat giant cell tumor of bone and high calcium levels due to cancer. The medication is given as an injection under the skin by a healthcare professional, typically once a month. Common side effects include nausea, tiredness, and diarrhea. Several biosimilar versions of Xgeva (denosumab) are also available.

Indications for Xgeva

Prevention of bone problems in adults with multiple myeloma or certain cancers that have spread to the bones
Giant cell tumor of bone in adults and certain teens who can't have surgery
High calcium levels caused by cancer (hypercalcemia of malignancy) in adults after bisphosphonate treatment hasn't worked

Pros and Cons for Xgeva

Pros

Helps reduce serious bone problems caused by cancers
Can be used for many cancer-related bone conditions
Typically injected once a month

Cons

Must be injected by a healthcare professional
Requires regular blood tests
Not safe in pregnancy

Common Side Effects for Xgeva

Cancer that has spread to the bones:

Tiredness (45%)
Low phosphate levels (32%)
Nausea (31%)

Multiple myeloma:

Diarrhea (34%)
Nausea (32%)
Low red blood cells (22%)
Back pain (21%)

Giant cell tumor of bone: (all ≥ 10%)

Joint pain
Back pain
Pain in the arms and legs
Tiredness
Headache
Nausea
Common cold symptoms
Muscle or bone pain
Toothache
Vomiting
Low phosphate levels
Constipation
Diarrhea
Cough

High calcium due to cancer:

Nausea (30%)
Shortness of breath (27%)
Reduced appetite (24%)
Headache (24%)
Swelling (24%)
Vomiting (24%)
Low red blood cell count (21%)
Constipation (21%)
Diarrhea (21%)

Warnings for Xgeva

Serious allergic reactions
Low calcium levels
Jaw bone problems (osteonecrosis of the jaw)
Thigh bone fractures
High calcium levels after stopping treatment
Spinal fractures after stopping treatment
Harm to unborn baby

Prices with our coupons for Xbryk vs. Xgeva

Xbryk1 vial / 1.7ml of 120mg/1.7ml

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Xgeva1 vial / 1.7ml of 120mg/1.7ml

$3,417.35$4,168.30

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Xbryk vs. Xgeva

Xbryk

Xgeva

Summary for Xbryk

Indications for Xbryk

Pros and Cons for Xbryk

Pros

Cons

Common Side Effects for Xbryk

Warnings for Xbryk

Summary for Xgeva

Indications for Xgeva

Pros and Cons for Xgeva

Pros

Cons

Common Side Effects for Xgeva

Warnings for Xgeva

Prices with our coupons for Xbryk vs. Xgeva

Browse medications by letter

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Xbryk

Xgeva

Summary for Xbryk

Indications for Xbryk

Pros and Cons for Xbryk

Pros

Cons

Common Side Effects for Xbryk

Warnings for Xbryk

Summary for Xgeva

Indications for Xgeva

Pros and Cons for Xgeva

Pros

Cons

Common Side Effects for Xgeva

Warnings for Xgeva