Key takeaways
Vyvgart (efgartigimod alfa) and Vyvgart Hytrulo (efgartigimod alfa / hyaluronidase) are both medications that treat generalized myasthenia gravis (gMG) in adults. Vyvgart is given as an IV infusion at a healthcare facility, while Vyvgart Hytrulo can be injected under the skin at home. Both medications contain the same active ingredient, but Vyvgart Hytrulo also includes hyaluronidase, which helps the medication absorb better when injected under the skin. Vyvgart Hytrulo is also FDA-approved for chronic inflammatory demyelinating polyneuropathy (CIDP), while Vyvgart is not. Common side effects of Vyvgart and Vyvgart Hytrulo include headaches and an increased risk of infections. It's important to monitor for signs of infection and avoid live vaccines while using them.
