Vyvgart
(efgartigimod alfa)
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Summary for Vyvgart
Vyvgart (efgartigimod alfa or efgartigimod alfa-fcab) is an FDA-approved IV injection that's used to treat adults with generalized myasthenia gravis (gMG). It belongs to a drug class called neonatal Fc receptor blockers, which work by lowering harmful antibodies that interferes with communication between your nerves and muscles. The medication is given IV, typically at an infusion center, your prescriber's office, or at home. Common side effects include respiratory tract infections, headache, and urinary tract infection (UTIs).
Indications for Vyvgart
- Generalized myasthenia gravis (gMG) in adults
Pros and Cons for Vyvgart
Pros
- Starts to work within 1 to 2 weeks
- Only injected once a week per treatment cycle
- Treatment cycles can last several weeks
- Approved for all types of gMG in adults
Cons
- Must be given by IV infusion
- Can often cause headache
- Can raise the risk of infections
- Not a cure for gMG
Common Side Effects for Vyvgart
- Respiratory tract infection (33%)
- Headache (32%)
- Urinary tract infection (10%)
Warnings for Vyvgart
- Infections
- Allergic reactions
- Infusion-related reactions
Summary for Vyvgart Hytrulo
Vyvgart Hytrulo (efgartigimod alfa and hyaluronidase-qvfc) is an injection used to treat adults with generalized myasthenia gravis (gMG). It's also FDA approved as a treatment for chronic inflammatory demyelinating polyneuropathy (CIDP). The medication comes in a vial or prefilled syringe, and it's injected under your skin. Common side effects include injection site reactions and headache.
Indications for Vyvgart Hytrulo
- Generalized myasthenia gravis (gMG) in adults
- Chronic inflammatory demyelinating polyneuropathy (CIDP)
Pros and Cons for Vyvgart Hytrulo
Pros
- Can be injected at home
- Injected under the skin
- FDA approved for all types of gMG, as well as CIDP
Cons
- Commonly causes injection site reactions
- Can raise the risk of infections
- Not a cure for gMG
Common Side Effects for Vyvgart Hytrulo
gMG
- Injection site reactions (38%)
- Headache (at least 10%)
CIDP
- Injection site reactions (15%)
Warnings for Vyvgart Hytrulo
- Infections
- Allergic reactions
- Injection-related reactions
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