Compare Vonjo vs. Jakafi
Head-to-head comparisons of medication uses, side effects, warnings, and more.
- Vonjo (pacritinib)Jakafi (ruxolitinib)
- Vonjo (pacritinib)Jakafi (ruxolitinib)
Summary of Vonjo vs. Jakafi
Summary for JAK inhibitorPrescription onlyVonjo (pacritinib) is a type of targeted therapy called a JAK inhibitor. It’s used to treat adults with a rare blood cancer called myelofibrosis (MF). This medication specifically helps people with MF who have very low platelet counts. Vonjo (pacritinib) is a capsule that you take by mouth twice a day. The medication might cause side effects like diarrhea, nausea, and swelling. It might also raise the risk of easy bleeding or bruising.
Summary for JAK inhibitorPrescription onlyJakafi (ruxolitinib) is a JAK inhibitor that’s used to treat adults with certain blood conditions called myelofibrosis (MF) and polycythemia vera (PV). This medication is also used to treat graft-versus-host disease (GVHD) in people 12 years and older. Jakafi (ruxolitinib) is a tablet that you take by mouth twice a day. It can cause side effects like low blood cell counts, infection, and tiredness.
Indications of Vonjo vs. Jakafi
Indications for•Intermediate or high-risk primary or secondary myelofibrosis (MF) in adults with a platelet count below 50,000/µLIndications for•Intermediate or high-risk myelofibrosis (MF) in adults•Acute graft-versus-host disease (aGVHD) in people 12 years and older who’ve already tried corticosteroids•Chronic graft-versus-host disease (cGVHD) in people 12 years and older who’ve already tried at least one therapy option alreadyPros and Cons of Vonjo vs. Jakafi
Pros and Const for JAK inhibitorPros•A pill that’s taken by mouth•Can take with or without food•Recommended treatment option for adults with myelofibrosis and low plateletsCons•Taken twice a day•Might cause side effects like bleeding and diarrhea•Might not be safe to take with certain medications because of drug interactionsPros and Const for JAK inhibitorPros•Taken by mouth; no needles required•Recommended treatment for myelofibrosis and polycythemia vera•Doesn’t typically cause nausea or vomiting•Works in a more targeted, specific way than traditional chemotherapyCons•Taken twice a day and might require dose changes often•Often causes low blood cell counts•Might raise your risk for infectionCommon Side Effects of Vonjo vs. Jakafi
Common Side Effects for•Diarrhea (48%)•Low platelets (34%)•Nausea (32%)•Anemia (24%)•Swelling in the hands, ankles, or feet (20%)•Vomiting (19%)•Dizziness (15%)•Fever (15%)Common Side Effects for•Infection (e.g., urinary tract infection, viral infection)•Muscle, bone, or joint pain•Anemia (low red blood cells)•Low platelets•High cholesterol levels•Higher liver enzyme levels in bloodWarnings of Vonjo vs. Jakafi
Common Side Effects for•Hemorrhage (bleeding)•Diarrhea•Low platelet count (thrombocytopenia)•Changes in heart rhythm•Risk of serious heart-related or blood-flow problems (e.g., heart attack, stroke)•Blood clots•Risk of new cancers•Higher risk of infection•Drug interactionsCommon Side Effects for•Low blood cell counts•Risk of infection•Risks when Jakafi (ruxolitinib) is paused or stopped•Skin cancer•Possible risk for serious heart problems and stroke•Possible risk for blood clots•Possible risk for new cancersPrices with our coupons for Vonjo vs. Jakafi
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