Vonjo vs. Jakafi for Myelofibrosis: Important Differences and Potential Risks.

Vonjo

(pacritinib)

Jakafi

(ruxolitinib)

Summary for Vonjo

Prescription only

Vonjo (pacritinib) is a type of targeted therapy called a JAK inhibitor. It’s used to treat adults with a rare blood cancer called myelofibrosis (MF). This medication specifically helps people with MF who have very low platelet counts. Vonjo (pacritinib) is a capsule that you take by mouth twice a day. The medication might cause side effects like diarrhea, nausea, and swelling. It might also raise the risk of easy bleeding or bruising.

Indications for Vonjo

Intermediate or high-risk primary or secondary myelofibrosis (MF) in adults with a platelet count below 50,000/µL

Pros and Cons for Vonjo

Pros

A pill that’s taken by mouth
Can take with or without food
Recommended treatment option for adults with myelofibrosis and low platelets

Cons

Taken twice a day
Might cause side effects like bleeding and diarrhea
Might not be safe to take with certain medications because of drug interactions

Common Side Effects for Vonjo

Diarrhea (48%)
Low platelets (34%)
Nausea (32%)
Anemia (24%)
Swelling in the hands, ankles, or feet (20%)
Vomiting (19%)
Dizziness (15%)
Fever (15%)

Warnings for Vonjo

Hemorrhage (bleeding)
Diarrhea
Low platelet count (thrombocytopenia)
Changes in heart rhythm
Risk of serious heart-related or blood-flow problems (e.g., heart attack, stroke)
Blood clots
Risk of new cancers
Higher risk of infection
Drug interactions

Summary for Jakafi

Prescription only

Jakafi (ruxolitinib) is a JAK inhibitor that’s used to treat adults with certain blood conditions called myelofibrosis (MF) and polycythemia vera (PV). This medication is also used to treat graft-versus-host disease (GVHD) in people 12 years and older. Jakafi (ruxolitinib) is a tablet that you take by mouth twice a day. It can cause side effects like low blood cell counts, infection, and tiredness.

Indications for Jakafi

Intermediate or high-risk myelofibrosis (MF) in adults
Polycythemia vera (PV) in adults who can’t take or have already tried hydroxyurea (Hydrea)
Acute graft-versus-host disease (aGVHD) in people 12 years and older who’ve already tried corticosteroids
Chronic graft-versus-host disease (cGVHD) in people 12 years and older who’ve already tried at least one therapy option already

Pros and Cons for Jakafi

Pros

Taken by mouth; no needles required
Recommended treatment for myelofibrosis and polycythemia vera
Doesn’t typically cause nausea or vomiting
Works in a more targeted, specific way than traditional chemotherapy

Cons

Taken twice a day and might require dose changes often
Often causes low blood cell counts
Might raise your risk for infection

Common Side Effects for Jakafi

Infection (e.g., urinary tract infection, viral infection)
Muscle, bone, or joint pain
Anemia (low red blood cells)
Low white blood cells
Low platelets
High cholesterol levels
Higher liver enzyme levels in blood

Warnings for Jakafi

Low blood cell counts
Risk of infection
Risks when Jakafi (ruxolitinib) is paused or stopped
Skin cancer
Possible risk for serious heart problems and stroke
Possible risk for blood clots
Possible risk for new cancers

Prices with our coupons for Vonjo vs. Jakafi

Vonjo120 capsules / 100mg

$25,672.33$28,526.10

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Jakafi60 tablets / 10mg

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Vonjo vs. Jakafi

Vonjo

Jakafi

Summary for Vonjo

Indications for Vonjo

Pros and Cons for Vonjo

Pros

Cons

Common Side Effects for Vonjo

Warnings for Vonjo

Summary for Jakafi

Indications for Jakafi

Pros and Cons for Jakafi

Pros

Cons

Common Side Effects for Jakafi

Warnings for Jakafi

Prices with our coupons for Vonjo vs. Jakafi

Browse medications by letter

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Vonjo

Jakafi

Summary for Vonjo

Indications for Vonjo

Pros and Cons for Vonjo

Pros

Cons

Common Side Effects for Vonjo

Warnings for Vonjo

Summary for Jakafi

Indications for Jakafi

Pros and Cons for Jakafi

Pros

Cons

Common Side Effects for Jakafi

Warnings for Jakafi