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Tranxene vs. Xanax

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Clorazepate (Tranxene) and alprazolam (Xanax) are both benzodiazepines used to treat anxiety, but they have some important differences. Clorazepate is also used for alcohol withdrawal and as an add-on treatment for partial seizures, while alprazolam is approved for generalized anxiety disorder (GAD) and panic disorder. Clorazepate is taken as a tablet, usually split into multiple doses throughout the day, while Alprazolam comes in immediate-release tablets, orally disintegrating tablets, and oral solution and typically starts working within 30 minutes. Both medications can cause drowsiness and should not be mixed with alcohol or opioids due to the risk of serious side effects. Clorazepate can stay in your system for 8 to 10 days after stopping, while alprazolam usually stays in your system 2-3 days. Both medications are controlled substance due to their risk of leading to misuse and dependence.

Clorazepate

(Tranxene)

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Alprazolam

(Xanax)

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Summary for Tranxene

Prescription only

Clorazepate (Tranxene) is a tablet that's taken by mouth used for anxiety, alcohol withdrawal symptoms, and as an add-on treatment for seizures. It's a controlled substance that belongs to a group of medications called benzodiazepines. The dosage is usually split up throughout the day. Because it stays in your body for a long time, you might continue to experience side effects, such as dizziness or tremors, even after you've stopped this medication. Clorazepate (Tranxene) might not be safe for older adults, children younger than 9 years old, and people with liver problems.

Indications for Tranxene

Pros and Cons for Tranxene

Pros

  • Available as a lower-cost generic
  • Approved for use in children age 9 and older for certain conditions
  • Possible add-on option for seizure if other medications aren't working
  • Dose can be adjusted based on your response

Cons

  • Can be habit-forming, so isn't typically used for long-term treatment (e.g., 4 months)
  • Can cause dangerous withdrawal symptoms if stopped abruptly
  • Stays in your body for a long time, even after you've stopped taking it
  • Can cause more side effects in older adults and people with liver problems

Common Side Effects for Tranxene

  • Drowsiness
  • Dizziness
  • Upset stomach
  • Blurry vision
  • Dry mouth
  • Feeling nervous
  • Headache
  • Confusion

Warnings for Tranxene

  • Trouble breathing, coma, and death
  • Misuse, dependency, and withdrawal
  • Difficulty with concentration and focus
  • Suicidal thoughts or behaviors
  • Harm to babies

Summary for Xanax

Prescription only

Alprazolam (Xanax) is a benzodiazepine. It's approved to treat generalized anxiety disorder (GAD) and panic attacks in adults. It's taken by mouth, typically 3 times a day or as directed by your healthcare team. To avoid the risk of dependence, alprazolam (Xanax) is meant for short-term treatment only. Some of the more common side effects of this medication include drowsiness and memory problems. You should avoid drinking alcohol while taking alprazolam (Xanax) because this can lead to serious interactions.

Indications for Xanax

Pros and Cons for Xanax

Pros

  • Taken by mouth
  • Can start to work in 30 minutes
  • Available as quick-dissolving tablets or liquid for people who have trouble swallowing pills

Cons

Common Side Effects for Xanax

Generalized anxiety disorder:

  • Drowsiness (41%)
  • Lightheadedness (21%)
  • Dry mouth (15%)

Panic disorder:

  • Drowsiness (77%)
  • Fatigue (49%)
  • Poor coordination (40%)
  • Memory issues (33%)
  • Irritability (33%)
  • Appetite changes (28-33%)
  • Thinking problems (29%)
  • Constipation (26%)

Side effects listed are for the immediate-release forms. Side effects for extended-release form might differ.

Warnings for Xanax

  • Sedation and difficulty breathing
  • Potential for misuse, addiction, dependence, and withdrawal
  • Effect on driving and concentration
  • Harm to babies
  • Interactions with other medications
  • Use with caution in people with depression

Prices with our coupons for Tranxene vs. Xanax

Price Card Drug Icon
Clorazepate30 tablets / 15mg
$30.91$131.50
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Price Card Drug Icon
Alprazolam30 tablets / 0.5mg
$10.40$14.84
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