Key takeaways
Dayquil (acetaminophen/dextromethorphan/phenylephrine ) and Sudafed (pseudoephedrine) are both used to relieve symptoms of the common cold, but they contain different ingredients. Dayquil is a combination medication that includes an analgesic, a cough suppressant, and a decongestant, while pseudoephedrine is a single-ingredient decongestant. Both medications are available over-the-counter, but pseudoephedrine is restricted and must be purchased at the pharmacy counter. Dayquil is typically taken every 4 hours, while Sudafed offers both immediate-release (every 4 to 6 hours) and extended-release (every 12 or 24 hours) options. Dayquil can cause side effects like stomach upset and nervousness, whereas Sudafed may lead to anxiety, headache, and difficulty sleeping. Both medications should not be taken with monoamine oxidase inhibitors (MAOIs) due to the risk of severe side effects. Additionally, Dayquil contains acetaminophen, which can cause liver damage if taken in excess or with alcohol, while Sudafed can raise blood pressure and heart rate.and should be used with caution if you have a history of heart problems.
