Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Flecainide (generic name: flecainide) and Amiodarone (generic name: amiodarone, brands: Pacerone, Nexterone) are both antiarrhythmic medications used to treat abnormal heart rhythms, but they have some key differences. Flecainide works by blocking sodium channels to slow down the heart's electrical activity, while Amiodarone blocks various receptors and channels in the heart. Flecainide is typically used for paroxysmal supraventricular tachycardias, paroxysmal atrial fibrillation/flutter, and ventricular arrhythmias, whereas Amiodarone is mainly used for preventing and treating recurrent ventricular arrhythmias. Flecainide is available as a generic and is taken orally, while Amiodarone is available both as a generic oral tablet and as an injection. Amiodarone must be started in a hospital due to its serious side effects, which include lung and liver damage, vision problems, and thyroid issues. Flecainide can cause dizziness and changes in vision but is not recommended for those with heart failure or a recent heart attack. Both medications require careful monitoring by a healthcare provider to avoid severe side effects and interactions with other medications.
Flecainide
Amiodarone (Pacerone)
Flecainide
Amiodarone (Pacerone)
Summary of Tambocor vs. Amiodarone
Summary for Antiarrhythmic
Prescription only
Flecainide helps normalize your heart rhythm if you have certain types of arrhythmias (abnormal heart rhythms). However it can cause dizziness and changes in vision.
Summary for Antiarrhythmic
Prescription only
Amiodarone (Pacerone) is an antiarrhythmic medication. It's FDA-approved to treat life-threatening ventricular fibrillation and fast heart rate (tachycardia) in adults who either can't take it or whose condition isn't well-controlled by other antiarrhythmics. It's sometimes prescribed off-label for atrial fibrillation (AFib). Amiodarone (Pacerone) comes as tablets that are taken by mouth. The total daily dose can be taken once per day, or split into smaller doses and taken throughout the day to prevent stomach-related side effects, like nausea and vomiting.
Indications of Tambocor vs. Amiodarone
Indications for
•Prevention of paroxysmal supraventricular tachycardias (PSVT)
•Prevention of paroxysmal atrial fibrillation/flutter (PAF)
•Prevention of ventricular arrhythmias
Indications for
•Life-threatening ventricular fibrillation that keeps coming back (when other antiarrhythmics haven't worked well)
•Life-threatening tachycardia that keeps coming back (when other antiarrhythmics haven't worked)
Pros and Cons of Tambocor vs. Amiodarone
Pros and Const for Antiarrhythmic
Pros
•Works good to treat certain types of irregular heart rhythms that could be life-threatening
•Is available as a cheaper generic formulation
Cons
•Not a preferred medication if you have heart failure or have had a recent heart attack
•Can cause dizziness or changes in vision
•Dosing needs to be adjusted if you have kidney or liver problems
Pros and Const for Antiarrhythmic
Pros
•Works well to treat certain heart rate and rhythm problems
•Can be taken with or without food
•Can be taken once daily (as long as you're tolerating the medication and the total daily dose is less than 1,000 mg)
Cons
•Stays in the body for many weeks
•Not for people with iodine allergy
•Only available as a 200 mg tablet, so you might need to take several tablets depending on your dose