Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Flecainide (generic name: flecainide) and Amiodarone (generic name: amiodarone, brands: Pacerone, Nexterone) are both antiarrhythmic medications used to treat abnormal heart rhythms, but they have some key differences. Flecainide works by blocking sodium channels to slow down the heart's electrical activity, while Amiodarone blocks various receptors and channels in the heart. Flecainide is typically used for paroxysmal supraventricular tachycardias, paroxysmal atrial fibrillation/flutter, and ventricular arrhythmias, whereas Amiodarone is mainly used for preventing and treating recurrent ventricular arrhythmias. Flecainide is available as a generic and is taken orally, while Amiodarone is available both as a generic oral tablet and as an injection. Amiodarone must be started in a hospital due to its serious side effects, which include lung and liver damage, vision problems, and thyroid issues. Flecainide can cause dizziness and changes in vision but is not recommended for those with heart failure or a recent heart attack. Both medications require careful monitoring by a healthcare provider to avoid severe side effects and interactions with other medications.
Flecainide
Amiodarone (Pacerone)
Flecainide
Amiodarone (Pacerone)
Summary of Tambocor vs. Amiodarone
Summary for Antiarrhythmic
Prescription only
Flecainide is a prescription antiarrhythmic medication used to prevent abnormal heart rhythms, including paroxysmal atrial fibrillation/flutter (PAF), paroxysmal supraventricular tachycardia (PSVT) and ventricular arrhythmias in adults and certain children. It comes as tablets that you take by mouth, typically two times a day, but your exact dose depends on your heart condition. Because it affects your heart rhythm, it requires regular heart monitoring. Common side effects include dizziness, vision changes, and shortness of breath.
Summary for Antiarrhythmic
Prescription only
Amiodarone (Pacerone) is an antiarrhythmic medication. It's FDA-approved to treat life-threatening ventricular fibrillation and fast heart rate (tachycardia) in adults who either can't take it or whose condition isn't well-controlled by other antiarrhythmics. It's sometimes prescribed off-label for atrial fibrillation (AFib). Amiodarone (Pacerone) comes as tablets that are taken by mouth. The total daily dose can be taken once per day, or split into smaller doses and taken throughout the day to prevent stomach-related side effects, like nausea and vomiting.