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Mucinex DM vs. Delsym

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Mucinex DM

(guaifenesin / dextromethorphan)

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Dextromethorphan

(Delsym)

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Summary for Mucinex DM

Over-the-counter

Mucinex DM (guaifenesin / dextromethorphan) is an over-the-counter medication that's used to relieve cough and loosen mucus. It has two active ingredients: guaifenesin (an expectorant that clears chest congestion) and dextromethorphan (a cough suppressant that relieves cough). The medication is available as tablets, dissolvable granules, and liquid that are taken by mouth, each with different dosages, directions, and age limits. Extended-release tablets are taken every 12 hours, while the other forms are usually taken every 4 hours. Most people have few to no side effects when used as directed, but it can sometimes cause stomach upset, dizziness, and drowsiness.

Indications for Mucinex DM

  • Short-term relief of coughs caused by minor throat or lung irritation (e.g., common cold)
  • Loosens and breaks up mucus in the airways (chest congestion)

Pros and Cons for Mucinex DM

Pros

  • Available as a tablet, oral liquid, and dissolvable granules
  • Available over the counter without a prescription
  • Sugar-free options available, so okay to use for people with high blood sugar
  • Works within 30 minutes to help lessen cough

Cons

  • Not meant to be used long-term
  • Might need to take multiple times a day to relieve symptoms
  • Many states require you to be over 18 to buy it because of risk of misuse
  • Can't cut or crush extended-release tablets

Common Side Effects for Mucinex DM

  • Side effects aren't common. See Other Side Effects.

Warnings for Mucinex DM

  • Risk of overdose and misuse
  • Interactions with certain medications for Parkinson's disease and depression
  • Caution use in people with phenylketonuria (PKU) - dissolvable granules only

Summary for Delsym

Over-the-counter

Dextromethorphan (Delsym) is an over-the-counter cough suppressant (antitussive). It helps relieve "dry" cough in adults and children by suppressing the cough reflex. Dextromethorphan (Delsym) is available as an extended-release (ER) cough syrup that's taken by mouth, typically every 12 hours. It also comes as an immediate-release (IR) caplet that's usually taken every 6 to 8 hours. Dextromethorphan might also come in additional formulations, under other brands. Some common side effects of dextromethorphan (Delsym) include nausea and stomach upset. Rarely, it can also make you sleepy.

Indications for Delsym

  • Short-term relief of cough caused by minor throat or lung irritation (e.g., common cold)

Pros and Cons for Delsym

Pros

  • Available as pills or oral liquids
  • Sugar-free options available
  • Available over the counter without a prescription

Cons

  • Might need to take multiple times a day
  • Meant for short-term treatment of cough only
  • Found in many OTC products, so you can accidentally take too much

Common Side Effects for Delsym

Warnings for Delsym

  • Overdose and misuse
  • Medication interactions

Prices with our coupons for Mucinex DM vs. Delsym

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Mucinex DM20 tablets / 600mg/30mg
$9.86$19.60
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Dextromethorphan180 capsules / 15mg
$31.75$46.93
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