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Polytrim vs. Besivance

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Polytrim

(polymyxin B / trimethoprim)

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Besivance

(besifloxacin)

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Summary for Polytrim

Prescription only

Polytrim (polymyxin B / trimethoprim) is a combination antibiotic eye drop. It's used to treat mild-to-moderate bacterial eye infections, such as pink eye, in adults and children ages 2 months and older. The typical dose is 1 drop applied directly in the eye(s) every 3 hours for 7 to 10 days. Some of the more common side effects of this eye drop include symptoms of eye irritation, such as redness, stinging, and itching. Polytrim (polymyxin B / trimethoprim) is available as a lower-cost generic.

Indications for Polytrim

  • Mild-to-moderate infections on the eye and eyelid

Pros and Cons for Polytrim

Pros

  • Can treat a variety of eye infections in adults and children
  • Available as a lower-cost generic
  • Applied directly on the eyes, so it has less side effects than oral antibiotics

Cons

  • Has to be used every 3 hours for at least a week
  • Can cause temporary eye irritation after applying
  • Can make your eyes more sensitive to light

Common Side Effects for Polytrim

  • Eye irritation (e.g., redness, burning, stinging, itching)

Warnings for Polytrim

  • For use in the eye only
  • New infection
  • Damage to contact lenses (when used in the eye)

Summary for Besivance

Prescription only

Besivance is a prescription eye drop used to treat bacterial pink eye in adults and children 1 year of age and older. It belongs to the fluoroquinolone antibiotic class. The dosage is typically 1 drop three times per day for 7 days to treat the eye infection. Currently it's available only as a brand-name medication as a generic is not yet available. Side effects aren't common, but include eye redness.

Indications for Besivance

  • Bacterial conjunctivitis (pink eye) in people ages 1 year and older

Pros and Cons for Besivance

Pros

  • Applied directly to the eye to target the infection
  • Side effects aren't common and are usually mild
  • Can be used in children as young as 1 year old

Cons

  • Can cause temporary eye redness or irritation
  • Can take days before you get symptom relief
  • No lower-cost generic is available

Common Side Effects for Besivance

  • Eye redness (2%)

Warnings for Besivance

  • Only for use on the surface of the eye
  • New or worsening eye infections

Prices with our coupons for Polytrim vs. Besivance

Price Card Drug Icon
Polymyxin B/Trimethoprim1 eye dropper / 10ml of 10000units/1mg/ml
$10.46$12.01
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Price Card Drug Icon
Besivance1 eye dropper / 5ml of 0.6%
$140.62$229.19
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