Compare Paxil vs. Lexapro

Paroxetine (Paxil) and escitalopram (Lexapro) are both selective serotonin reuptake inhibitors (SSRIs) used to treat depression and anxiety. However, they have some important differences. Paroxetine is available in both immediate-release and extended-release forms and is also approved for panic disorder, social anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, and premenstrual dysphoric disorder. Escitalopram, on the other hand, is specifically approved for depression and generalized anxiety disorder (GAD), but may be used off-label for other mental health conditions. Paroxetine can cause weight gain and sexual problems more frequently than escitalopram, which is generally considered to have fewer side effects than many other antidepressants. Both medications can cause withdrawal symptoms if stopped suddenly. Both medications are available as a brand and a lower-cost generic.