Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Memantine (Namenda) and Namzaric (memantine/donepezil) are both used to treat moderate-to-severe dementia related to Alzheimer's disease, but they have some key differences. Memantine is an NMDA antagonist that works by lowering the activity of certain chemical messengers in the brain to prevent nerve damage. It is available in both immediate-release and extended-release forms, and can be taken once or twice daily. Namzaric, on the other hand, is a combination of memantine and donepezil, an acetylcholinesterase inhibitor that raises acetylcholine levels in the brain. Namzaric is only available as an extended-release medication and is taken once daily, typically in the evening. While memantine can be used alone, Namzaric is prescribed when your condition is stable on donepezil 10 mg daily. Namzaric offers the convenience of combining two medications in one, but it is only available as a brand, making it potentially more expensive. Both medications can cause side effects like dizziness and headaches, but Namzaric has additional risks such as stomach ulcers and a slowed heartbeat.
Memantine (Nameda)
Namzaric (memantine / donepezil ER)
Memantine (Nameda)
Namzaric (memantine / donepezil ER)
Summary of Nameda vs. Namzaric
Summary for NMDA antagonist
Prescription only
Memantine (Nameda) is an NMDA antagonist used to treat moderate-to-severe dementia linked to Alzheimer's disease. It works by slowing down certain chemical activities in the brain to prevent nerve damage. Memantine (Nameda) is taken by mouth once or twice daily, depending on if you're taking the extended-release capsules, or the regular-release tablet or oral solution. Some side effects of memantine (Nameda) include dizziness, headaches, and confusion.
Summary for NMDA antagonist / Acetylcholinesterase inhibitor
Prescription only
Namzaric (memantine / donepezil ER) is a combination medication used to treat moderate-to-severe dementia in people with Alzheimer's disease. It contains memantine (an NMDA antagonist) and donepezil (an acetylcholinesterase inhibitor). It's only for people who are already taking 10 mg of donepezil daily, and it doesn't have generic versions available as of Fall 2024. The usual dosage is to take one capsule by mouth once daily in the evening. Some potential side effects include dizziness and diarrhea.