Key takeaways
Levofloxacin (Levaquin) and penicillin (Penicillin VK) are antibiotics used for bacterial infections but differ in their uses and side effects. Levofloxacin, a fluoroquinolone, treats a variety of infections such as skin, sinus, and respiratory infections, and is typically taken once daily. Penicillin VK, a penicillin antibiotic, is mainly used for strep throat, pneumonia, and certain skin infections, and must be taken every 6 to 8 hours. Levofloxacin can be taken if you’re allergic to penicillin but has serious side effects like tendon damage and nerve issues. Penicillin VK has fewer side effects but is less effective against resistant bacteria. Both have generic versions available, but levofloxacin interacts with more medications, so it's crucial to inform your healthcare provider about any other drugs you’re taking.
