Key takeaways
Doxycycline hyclate (Targadox, Doryx,) and minocycline (Minocin, Minolira, Solodyn, Ximino) are both tetracycline antibiotics used to treat various bacterial infections, including acne and urinary tract infections (UTIs). They also treat respiratory tract infections and sexually transmitted infections (STIs) like chlamydia and gonorrhea. However, doxycycline hyclate is also used for malaria prevention, while minocycline is not. Doxycycline hyclate is available in tablets, capsules, liquid syrup, and as an intravenous (IV) injection whereas minocycline is available in tablets, capsules, and as an IV injection. Doxycycline hyclate is typically taken once or twice daily, while minocycline is often taken every 12 hours or four times a day, depending on the condition. Both medications can cause sun sensitivity, but minocycline may also cause dizziness and skin darkening. Both medications can interact with antacids, blood thinners, and can affect birth control effectiveness. Both medications are not recommended during pregnancy due to potential harm to unborn babies.
