Key takeaways
Citalopram (Celexa) and bupropion (Wellbutrin XL, Wellbutrin SR) are both medications used to treat depression, but they belong to different medication classes. Citalopram is a selective serotonin reuptake inhibitor (SSRI), while bupropion is an atypical antidepressant. Citalopram is typically taken once daily and is also available in a liquid form, whereas bupropion comes in immediate-release, sustained-release, and extended-release tablets, with dosing varying from once to three times daily depending on the formulation. Bupropion is also FDA-approved for treating seasonal affective disorder (SAD), which is not an indication for citalopram. Common side effects of citalopram include nausea and dry mouth, while bupropion may cause headaches and trouble sleeping. Both medications can interact with medications affecting serotonin levels, increasing the risk of serotonin syndrome, while bupropion has a higher risk of seizures, especially in those with a history of seizures or eating disorders. Both medications are available in generic forms, making them more affordable options for treating depression.
