Key takeaways
Buspirone (Buspar) and bupropion (Wellbutrin XL, Forfivo XL) are both oral prescription medications used for mental health conditions, but they have some impotant differences. Buspirone is an antianxiety medication used to relieve anxiety, while bupropion is an atypical antidepressant used to treat depression and seasonal affective disorder (SAD). Buspirone is typically taken twice daily, whereas bupropion is available in short-acting and long-acting forms, with dosing ranging from once to three times daily depending on the formulation. Both medications are available as a lower-cost generic. Common side effects of buspirone include dizziness and headache, while bupropion can cause headaches and trouble sleeping. Buspirone has a lower risk of dependency and withdrawal symptoms compared to other anxiety medications, like benzodiazepines. Bupropion increases the risk of seizures and is not recommended for those with a history of seizures or eating disorders. Buspirone interacts with many medications and grapefruit juice, while bupropion can interact with alcohol and other medications that affect blood pressure.
