Key takeaways
Disulfiram (formerly branded as Antabuse) and Vivitrol (naltrexone) are both used to treat alcohol use disorder, but they work in different ways and have different forms. Disulfiram is an oral tablet taken daily that makes you feel sick if you drink alcohol, while Vivitrol is a monthly injection that blocks the feel-good effects of alcohol and opioids. Disulfiram is available as a generic, but Vivitrol is only available as a brand-name medication. Disulfiram requires you to avoid all alcohol, even in small amounts, to prevent severe reactions, whereas Vivitrol helps reduce cravings for alcohol and opioids. Vivitrol also treats opioid use disorder, while disulfiram does not. Both medications should be used alongside therapy and support groups for the best results.
